Immunogen sequence: AVEHMFEGEH GSKDEWRGMV LAQAPIMKAW FYITYEKDPV LYMYQLLDDY KEGDLRIMPE SSESPPTERE PGGVVDGLIG KHVEYTKEDG SKRIGMVIHQ VEAKPSV
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.
Human SPIN2 expressed by 2 IL3-dependent murine myeloid cell lines was moderately antiapoptotic following IL3 removal, but it was unable to block apoptosis induced by the chemotherapy agent doxorubicin. On the contrary, SPIN2-expressing cells were more sensitive to doxorubicin-mediated cell death. Also, SPIN2 did not combat the proapoptotic effects of Fas ligand stimulation in the Jurkat human T-cell line. Deletion of the C-terminal amino acids of SPIN2 diminished its antiapoptotic activity. In the murine myeloid cells, SPIN2 overexpression increased the cell number doubling times and slowed their rate of growth. There was also an increased percentage of cells in G2/M, which was more pronounced following IL3 withdrawal.
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Protein Aliases: SPIN-2; Spindlin 2B; spindlin family, member 2 duplicate; spindlin family, member 2B; Spindlin-2B; Spindlin-like protein 2B; telomeric SPIN2 copy
Gene Aliases: dJ323P24.2; SPIN-2; SPIN-2B; SPIN2; SPIN2_duplicate; SPIN2B; TDRD26
UniProt ID: (Human) Q9BPZ2
Entrez Gene ID: (Human) 474343