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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • SPO11 Antibodies

          Bioss

          SPO11 Polyclonal Antibody

          View all (7) SPO11 antibodies

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          Cite SPO11 Polyclonal Antibody

          Additional Information:
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          Product Details

          BS-9302R

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          Assay-dependent
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:100-1:500
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human SPO11.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: Cancer/testis antigen 35; CT35; Meiotic recombination protein SPO11; MGC39953; spermatogenesis associated 43; SPO11 meiotic protein covalently bound to DSB homolog; sporulation protein, meiosis-specific, SPO11 homolog; sporulation protein, meiosis-specific, SPO11 homolog (S. cervisiae)

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          Gene Aliases: AI449549; CT35; SPATA43; SPO11; TOPVIA

          View more View less

          UniProt ID: (Human) Q9Y5K1, (Mouse) Q9WTK8

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          Entrez Gene ID: (Human) 23626, (Mouse) 26972, (Rat) 366261

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          Function(s)
          DNA binding DNA topoisomerase type II (ATP-hydrolyzing) activity protein binding ATP binding metal ion binding catalytic activity hydrolase activity DNA metabolism protein endodeoxyribonuclease nucleic acid metabolism protein
          Process(es)
          DNA catabolic process, endonucleolytic ovarian follicle development synaptonemal complex assembly reciprocal meiotic recombination male meiosis I spermatogenesis spermatid development female gamete generation protein localization to chromosome meiotic telomere clustering oogenesis DNA metabolic process synapsis meiotic cell cycle
          It has to be done as per old AB suggested Products section.
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          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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