Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139- dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hIMP1; histocompatibility (minor) 13; histocompatibility 13; IMP-1; Intramembrane protease 1; minor histocompatibility antigen 13; Minor histocompatibility antigen H13; presenilin-like aspartyl protease; Presenilin-like protein 3; Signal peptide peptidase; signal peptide peptidase beta; signal peptide peptidase like 1
Gene Aliases: 1200006O09Rik; 4930443L17Rik; 5031424B04Rik; AV020344; H-13; H13; HM13; IMP1; IMPAS; IMPAS-1; MSTP086; PSENL3; PSL3; SPP; SPPL1