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Proteintech
SPP2 Polyclonal Antibody
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Product Details
30922-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPP2 fusion protein Ag29299
Conjugate
Form
Liquid
Concentration
400 µg/mL
Amount
60 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: FPVYDYDPSS LRDALSASVV KVNSQSLSPY LFRAFRSSLK RVEVLDENNL VMNLEFSIRE TTCRKDSGED PATCAFQRDY YVSTAVCRST VKVSAQQVQG VHARCSWSSS TSESYSSEEM IFGDMLGSHK WRNNYLFGLI SDESISEQFY DRSLGIMRRV LPPGNRRYPN HRHRARINTD FE
Target Information
SPP24, also known as secreted phosphoprotein 2, is a 211 amino acid secreted protein that belongs to the cystatin superfamily. Expressed in liver and plasma, SPP24 may play a role in coordinating an aspect of bone turnover. The gene that encodes SPP24 maps to human chromosome 2, which consists of 237 million bases encoding over 1,400 genes, making up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr syndrome is due to mutations in the ALMS1 gene. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes seen in modern form today in apes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Secreted phosphoprotein 2; secreted phosphoprotein 2, 24kD; secreted phosphoprotein 2, 24kDa; Secreted phosphoprotein 24; Spp-24
Gene Aliases: SPP-24; SPP2; SPP24
UniProt ID: (Human) Q13103
Entrez Gene ID: (Human) 6694
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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