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Proteintech
SPPL2A Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
13255-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPPL2A Fusion Protein Ag3935 (361-520 aa encoded by BC025740)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ITKNGESIM VELAAGPFGN NEKLPVVIRV PKLIYFSVMS VCLMPVSILG FGDIIVPGLL IAYCRRFDVQ TGSSYIYYVS STVAYAIGMI LTFVVLVLMK KGQPALLYLV PCTLITASVV AWRRKEMKKF WKGNSYQMMD HLDCATNEEN PVISGEQIVQ Q (361-520 aa encoded by BC025740)
Target Information
By searching sequence databases for homologs of Dictyostelium discoideum Impas, which shares homology with presenilin, followed by PCR of lymphocyte and hippocampus cDNA libraries, Grigorenko et al. (2002) cloned SPPL2a. This protein, which may act as an intramembrane protease, contains an N-terminal protease-associated (PA) domain, several transmembrane regions, a hydrophilic loop, conservative sequences around the first and second aspartate residues, and an invariant PAL motif near the C terminus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IMP-3; IMPAS; intramembrane cleaving protease; intramembrane protease 3; presenilin-like protein 2; protein SPPL2a; SPP-like 2A; SPP-like 2A protein; SPPL2a protein; unnamed protein product
Gene Aliases: 2010106G01Rik; C130089K23Rik; IMD86; IMP3; PSL2; RGD1563001
UniProt ID: (Human) Q8TCT8, (Mouse) Q9JJF9
Entrez Gene ID: (Human) 84888, (Rat) 311401, (Mouse) 66552
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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