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Immunogen sequence: ITKNGESIM VELAAGPFGN NEKLPVVIRV PKLIYFSVMS VCLMPVSILG FGDIIVPGLL IAYCRRFDVQ TGSSYIYYVS STVAYAIGMI LTFVVLVLMK KGQPALLYLV PCTLITASVV AWRRKEMKKF WKGNSYQMMD HLDCATNEEN PVISGEQIVQ Q (361-520 aa encoded by BC025740)
By searching sequence databases for homologs of Dictyostelium discoideum Impas, which shares homology with presenilin, followed by PCR of lymphocyte and hippocampus cDNA libraries, Grigorenko et al. (2002) cloned SPPL2a. This protein, which may act as an intramembrane protease, contains an N-terminal protease-associated (PA) domain, several transmembrane regions, a hydrophilic loop, conservative sequences around the first and second aspartate residues, and an invariant PAL motif near the C terminus.
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Protein Aliases: IMP-3; intramembrane cleaving protease; Intramembrane protease 3; Presenilin-like protein 2; protein SPPL2a; Signal peptide peptidase-like 2A; SPP-like 2A; SPP-like 2A protein; SPPL2a protein
Gene Aliases: 2010106G01Rik; C130089K23Rik; IMP3; MNCb-3763; PSEC0147; PSL2; RGD1563001; SPPL2A
Molecular Function: aspartic protease