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Invitrogen
SPPL3 Polyclonal Antibody
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FIGURE: 1 / 2
SPPL3 Antibody (PA5-113253) in WB
Western blot analysis of SPPL3 in multiple sample types using a SPPL3 polyclonal antibody (Product # PA5-113253) at a dilution of 1:2,000. A goat anti rabbit polyclonal secondary antibody was used at a dilution of 1:50,000. Sample types that were tested include: Hela whole cell lysate, U87 whole cell lysate, SY5Y whole cell lysate, A549 whole cell lysate, HL-60 whole cell lysate, 293T whole cell lysate, K562 whole cell lysate, mouse brain tissue, and rat brain tissue.
Product Details
PA5-113253
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Signal peptide peptidase-like 3 protein (213-263AA)
Conjugate
Form
Liquid
Concentration
0.99 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Signal peptide peptidase (SPP) is an aspartyl protease that mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, SPP contains a critical GXGD motif in its C-terminal catalytic center. SPPL3 is one of several presenilin homologues/SPP-like proteins (PSHs/SPPL) that have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IMP-2; Intramembrane protease 2; Presenilin homologous protein 1; Presenilin-like protein 4; PSH1; signal peptide peptidase 3; signal peptide peptidase like 3; Signal peptide peptidase-like 3; signal peptide peptidase-like 3, pseudogene 1; SPP-like 3; SPP-like 3 protein; upregulated during skeletal muscle growth 3
Gene Aliases: 4833416I09Rik; IMP2; MDHV1887; PRO4332; PSH1; PSL4; RGD1562826; SPPL3; Sppl3-ps1; Usmg3
UniProt ID: (Human) Q8TCT6, (Mouse) Q9CUS9
Entrez Gene ID: (Human) 121665, (Mouse) 74585, (Rat) 360822
signal peptide processing
membrane protein ectodomain proteolysis
positive regulation of cytosolic calcium ion concentration
positive regulation of protein binding
membrane protein proteolysis
positive regulation of protein dephosphorylation
T cell receptor signaling pathway
positive regulation of NFAT protein import into nucleus
positive regulation of calcineurin-NFAT signaling cascade
proteolysis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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