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Invitrogen
SPRY2 Polyclonal Antibody
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Product Details
PA5-43583
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human SPRY2 (aa 1-50).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: MEARAQSGNG SQPLLQTPRD GGRQRGEPDP RDALTQQVHV LSLDQIRAIR
Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 92%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 86%; Rat: 100%
Target Information
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: h-Spry2; membrane-associated protein; MGC23039; Protein sprouty homolog 2; Spry-2; unnamed protein product
Gene Aliases: hSPRY2; IGAN3; SPRY2
UniProt ID: (Human) O43597
Entrez Gene ID: (Human) 10253
establishment of mitotic spindle orientation
sensory perception of sound
negative regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
regulation of signal transduction
positive regulation of gene expression
negative regulation of epithelial to mesenchymal transition
negative regulation of angiogenesis
lung development
positive regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cell projection organization
negative regulation of protein ubiquitination
positive regulation of peptidyl-serine phosphorylation
cellular response to vascular endothelial growth factor stimulus
negative regulation of fibroblast growth factor receptor signaling pathway
inner ear morphogenesis
negative regulation of apoptotic process
cell fate commitment
positive regulation of epidermal growth factor receptor signaling pathway
negative regulation of Ras protein signal transduction
animal organ development
branching morphogenesis of an epithelial tube
negative regulation of neurotrophin TRK receptor signaling pathway
positive regulation of protein kinase B signaling
lung morphogenesis
lung growth
bud elongation involved in lung branching
respiratory system development
ERK1 and ERK2 cascade
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
negative regulation of vascular endothelial growth factor signaling pathway
negative regulation of lens fiber cell differentiation
cellular response to leukemia inhibitory factor
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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