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Immunogen sequence: MASSAKSAE MPTISKTLNP TPDPHQEYLD PRITIALFEI GSHSPSSWGS LPFLKNSSHQ VTEQQTAQKF NNLLKEIKDI LKNMAGFEEK ITEAKELFEE TNITEDVSAH KENIRGLDKI NEMLSTNLPV SLAPEKEDNE KKQEMILETN ITEDVSAHKE NIRGLDKINE MLSTNLPVSL APEKEDNEKK QQMIMENQNS ENTAQVFARD LVNRLEEKKV LNETQQSQEK AKNRLNVQEE TMKIRNNMEQ LLQEAEHWSK QHTELSKLIK SYQKSQKDIS ETLGNNGVGF QTQPNNEVSA KHELEEQVKK LSHDTYSLQL MAALLENECQ ILQQRVEILK ELHHQKQGTL QEKPIQINYK QDKKNQKPSE AKKVEMYKQN KQAMKGTFWK KDRSCRSLDV CLNKKACNTQ FNIHVARKAL RGKMRSASSL R (1-430 aa encoded by BC033798)
Spermatogenic leucine zipper protein 1 is a member of the basic helix-loop-helix (bHLH) family of transcription factors which is expressed specifically in the testis and epididymis. Studies show that SPZ1 acts downstream of mitogen-activated protein kinase (MAPK), an extracellular signal-regulated kinase 1/2 to up-regulate cell proliferation and tumorigenesis. Also, through an interaction with proliferating cell nuclear antigen (PCNA) promoter, SPZ1 induced cell proliferation concomitant with an increase in PCNA gene expression.
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Protein Aliases: protein phosphatase 1, regulatory subunit 148; Spermatogenic leucine zipper protein 1; spermatogenic zip 1; testis secretory sperm-binding protein Li 232m; Testis-specific protein 1; Testis-specific protein NYD-TSP1
Gene Aliases: NYD-TSP1; PPP1R148; SPZ1; TSP1
UniProt ID: (Human) Q9BXG8
Entrez Gene ID: (Human) 84654