Spermatogenic leucine zipper protein 1 is a member of the basic helix-loop-helix (bHLH) family of transcription factors which is expressed specifically in the testis and epididymis. Studies show that SPZ1 acts downstream of mitogen-activated protein kinase (MAPK), an extracellular signal-regulated kinase 1/2 to up-regulate cell proliferation and tumorigenesis. Also, through an interaction with proliferating cell nuclear antigen (PCNA) promoter, SPZ1 induced cell proliferation concomitant with an increase in PCNA gene expression.
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Protein Aliases: protein phosphatase 1, regulatory subunit 148; Spermatogenic leucine zipper protein 1; spermatogenic zip 1; testis secretory sperm-binding protein Li 232m; Testis-specific protein 1; Testis-specific protein NYD-TSP1
Gene Aliases: NYD-TSP1; PPP1R148; SPZ1; TSP1
UniProt ID: (Human) Q9BXG8
Entrez Gene ID: (Human) 84654