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|Tested species reactivity||Human, Mouse, Primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (55 NSSHQVTEQQTAQKFN 70) of SPZ1 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Spermatogenic leucine zipper protein 1 is a member of the basic helix-loop-helix (bHLH) family of transcription factors which is expressed specifically in the testis and epididymis. Studies show that SPZ1 acts downstream of mitogen-activated protein kinase (MAPK), an extracellular signal-regulated kinase 1/2 to up-regulate cell proliferation and tumorigenesis. Also, through an interaction with proliferating cell nuclear antigen (PCNA) promoter, SPZ1 induced cell proliferation concomitant with an increase in PCNA gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
bhlh-zip transcription factor SPZ1; NYD-TSP1; protein phosphatase 1, regulatory subunit 148; spermatogenic leucine zipper protein 1; spermatogenic Zip 1; testis secretory sperm-binding protein Li 232m; testis-specific protein 1
1700027M20Rik; AI429130; NYD-TSP1; PPP1R148; SPZ1; TSP1