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Invitrogen

SQSTM1 Recombinant Rabbit Monoclonal Antibody (R3F5)

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Product Details

MA572233

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:20,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunohistochemistry (Frozen) (IHC (F))

1:200-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

1 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

R3F5

Immunogen

A synthesized peptide derived from human Sequestosome 1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: autophagy receptor p62; EBI3-associated protein of 60 kDa; EBI3-associated protein p60; EBIAP; oxidative stress induced; oxidative stress induced like; p62; p62 transcript variant 4; p62 transcript variant 5; phosphotyrosine independent ligand for the Lck SH2 domain p62; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; PKC-zeta-interacting protein; Protein kinase C-zeta-interacting protein; Sequestosome-1; STONE14; Ubiquitin-binding protein p62; unnamed protein product

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Gene Aliases: A170; DMRV; EBIAP; FTDALS3; NADGP; ORCA; OSF-6; Osi; OSIL; p60; p62; p62B; PDB3; SQSTM1; STAP; STONE14; ZIP; ZIP3

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UniProt ID: (Human) Q13501, (Rat) O08623, (Mouse) Q64337

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Entrez Gene ID: (Human) 8878, (Rat) 113894, (Mouse) 18412

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Function(s)
protein kinase C binding protein binding zinc ion binding enzyme binding protein kinase binding protein binding, bridging receptor tyrosine kinase binding ubiquitin protein ligase binding ionotropic glutamate receptor binding signaling receptor activity SH2 domain binding identical protein binding ubiquitin binding macromolecular complex binding metal ion binding K63-linked polyubiquitin binding ubiquitin-dependent protein binding protein sequestering activity molecular sequestering activity molecular condensate scaffold activity protein homodimerization activity transcription cofactor activity
Process(es)
positive regulation of protein phosphorylation immune system process ubiquitin-dependent protein catabolic process autophagy apoptotic process macroautophagy positive regulation of macroautophagy cell differentiation regulation of I-kappaB kinase/NF-kappaB signaling protein heterooligomerization regulation of mitophagy negative regulation of transcription from RNA polymerase II promoter mitophagy mitophagy pexophagy temperature homeostasis response to ischemia transcription from RNA polymerase II promoter protein import into nucleus endosome organization protein localization positive regulation of autophagy regulation of mitochondrion organization endosomal transport protein catabolic process negative regulation of protein ubiquitination cellular response to stress toll-like receptor 4 signaling pathway negative regulation of toll-like receptor 4 signaling pathway intracellular signal transduction aggrephagy positive regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter regulation of Ras protein signal transduction regulation of protein complex stability brown fat cell proliferation protein K63-linked ubiquitination protein targeting to vacuole involved in autophagy energy homeostasis response to mitochondrial depolarisation negative regulation of ferroptosis membraneless organelle assembly positive regulation of long-term synaptic potentiation positive regulation of protein localization to plasma membrane protein localization to perinuclear region of cytoplasm mitophagy in response to mitochondrial depolarization regulation of nucleic acid-templated transcription
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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