PA5-29789 targets SR-BI in IHC (P), ICC/IF and WB applications and shows reactivity with Human samples.
The PA5-29789 immunogen is recombinant protein fragment corresponding to a region within amino acids 290 and 492 of Human SR-BI.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.
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Protein Aliases: CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen-like 1; CD36L1; CLA-1; CLA1; Collagen type I receptor, thrombospondin receptor-like 1; HDLQTL6; Scavenger receptor class B member 1; scavenger receptor class B type III; scavenger receptor class B, member 1; SR-BI; SRB1; thrombospondin receptor)-like 1
Gene Aliases: CD36L1; CLA-1; CLA1; HDLQTL6; SCARB1; SR-BI; SRB1
UniProt ID: (Human) Q8WTV0
Entrez Gene ID: (Human) 949
Molecular Function: receptor