Immunogen sequence: MGCSAKARWA AGALGVAGLL CAVLGAVMIV MVPSLIKQQV LKNVRIDPSS LSFNMWKEIP IPFYLSVYFF DVMNPSEILK GEKPQVRERG PYVYREFRHK; Positive Samples: Rat ovary; Cellular Location: Cell membrane, Membrane, Multi-pass membrane protein, caveola
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
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Protein Aliases: CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen-like 1; CLA-1; Collagen type I receptor, thrombospondin receptor-like 1; HDL QTL 1; scavanger receptor class B type 1; Scavenger receptor class B member 1; scavenger receptor class B type I; scavenger receptor class B type III; scavenger receptor class B, member 1; scavenger receptor class B1; SR-BI; SRB1
Gene Aliases: AI120173; CD36; CD36L1; CLA-1; CLA1; D5Ertd460e; Hdlq1; HDLQTL6; Hlb398; mSR-BI; SCARB1; SR-B1; SR-BI; SRB1; SRBI
Molecular Function: receptor