The antibody detects endogenous levels of total SRGAP2 protein.
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes.
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Protein Aliases: FBP-27; formin binding protein 2; Formin-binding protein 2; Formin-binding protein 27; Rho GTPase-activating protein 34; SLIT-ROBO GAP2; SLIT-ROBO Rho GTPase-activating protein 2; srGAP2
Gene Aliases: 9930124L22Rik; AI448945; ARHGAP34; FBP2; Fbp27; FNBP2; KIAA0456; RGD1566016; SRGAP2; SRGAP2A; SRGAP3
Molecular Function: GTPase-activating protein