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Invitrogen
SRGAP2 Polyclonal Antibody
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SRGAP2 Antibody (PA5-78445) in IHC (P)
SRGAP2 Polyclonal Antibody detects SRGAP2 protein at cell membrane and cytoplasm in rat liver by immunohistochemical analysis. Sample: Paraffin-embedded rat liver. SRGAP2 Polyclonal Antibody (Product # PA5-78445) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
PA5-78445
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human SRGAP2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: 293T, A431, HeLa, HepG2, mouse brain, rat brain
Predicted Reactivity: Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FBP-27; formin binding protein 2; Formin-binding protein 2; Formin-binding protein 27; Rho GTPase-activating protein 34; SLIT-ROBO GAP2; SLIT-ROBO Rho GTPase-activating protein 2; srGAP2
Gene Aliases: 9930124L22Rik; AI448945; ARHGAP34; FBP2; Fbp27; FNBP2; KIAA0456; RGD1566016; SRGAP2; SRGAP2A; SRGAP3
UniProt ID: (Human) O75044, (Rat) D4A208, (Mouse) Q91Z67
Entrez Gene ID: (Human) 23380, (Rat) 360840, (Mouse) 14270
lamellipodium assembly involved in ameboidal cell migration
signal transduction
cell proliferation
extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
substrate adhesion-dependent cell spreading
positive regulation of GTPase activity
filopodium assembly
neuron projection morphogenesis
actin filament severing
regulation of small GTPase mediated signal transduction
negative regulation of cell death
dendritic spine development
negative regulation of neuron migration
negative regulation of cell migration
nervous system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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