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Product Details
11845-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 3 publications 3 publications |
Immunohistochemistry (IHC) |
- | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunohistochemistry (PFA fixed) (IHC (PFA)) |
1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
SRPX2 Fusion Protein Ag2516 (166-465 aa encoded by BC020733) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.14 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: DGRWSGGEP VCVDIDPPKI RCPHSREKMA EPEKLTARVY WDPPLVKDSA DGTITRVTLR GPEPGSHFPE GEHVIRYTAY DRAYNRASCK FIVKVQVRRC PTLKPPQHGY LTCTSAGDNY GASCEYHCDG GYDRQGTPSR VCQSSRQWSG SPPICAPMKI NVNVNSAAGL LDQFYEKQRL LIISAPDPSN RYYKMQISML QQSTCGLDLR HVTIIELVGQ PPQEVGRIRE QQLSANIIEE LRQFQRLTRS YFNMVLIDKQ GIDRDRYMEP VTPEEIFTFI DDYLLSNQEL TQRREQRDIC E (166-465 aa encoded by BC020733)
Target Information
Sushi-repeat-containing protein X-linked 2 (SRPX2) is a neural gene functioning in the speech and language center of the human brain; mutations in this gene lead to epilepsy, speech dyspraxia, mental retardation and cognitive disorders. Recently, SRPX2 was found to be a novel mediator of angiogenesis and can act as a ligand for the urokinase-type plasminogen activator, a protein that can facilitate invasive migration of sprouting endothelial cells. SRPX2 is also overexpressed in gastric cancer, leading to increased phosphorylation levels of focal adhesion kinase and enhanced cellular migration and adhesion, suggesting that SRPX2 may be a potential target in the treatment of metastatic cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: RP11-524D16__A.1; srpx2 {ECO:0000312|EMBL:AAI68975.1, ECO:0000312|RGD:1562444}; Sushi repeat-containing protein SRPX2; sushi repeat-containing protein SRPX2 {ECO:0000303|PubMed:24179158}; sushi-repeat containing protein; sushi-repeat containing protein, X-linked 2; sushi-repeat protein up-regulated in leukemia; Sushi-repeat protein upregulated in leukemia; sushi-repeat-containing protein, X-linked 2
Gene Aliases: 1110039C07Rik; BPP; CBPS; PMGX; RESDX; RGD1562444; SRP; SRPUL; SRPX2
UniProt ID: (Human) O60687, (Rat) B5DF94, (Mouse) Q8R054
Entrez Gene ID: (Human) 27286, (Rat) 317181, (Mouse) 68792
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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