PA3-109 detects Somatostatin Receptor 2A in human and rat samples.
PA3-109 has been used successfully in Western blot, immunocytochemistry, and immunohistochemistry procedures. In Western blot analysis of SSTR2A transfected HEK-293 cells this antibody detects a ~62-72 kDa protein representing SSTR2A.
The PA3-109 immunogen is a synthetic peptide corresponding to residues E(355) T Q R T L L N G D L Q T S I(369) of human SSTR2A.
SSTR2 (somatostatin receptor 2) is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in the cerebrum and kidney. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The receptor is coupled via pertussis toxin sensitive G proteins to inhibit adenylyl cyclase.
Protein Aliases: somatostatin receptor; somatostatin receptor 2a; somatostatin receptor subtype 2; Somatostatin receptor type 2; somatotropin release-inhibiting factor receptor; SRIF-1; SS-2-R; SS2-R; SS2R; SSR2; SSTR2A
Gene Aliases: Smstr2; SSTR2