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Invitrogen
SSTR3 Polyclonal Antibody
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Product Details
PA3-110
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues C Q(385) E R P P S R V A(393) of human SSTR3.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA3-110 detects the Somatostatin Receptor 3 in human samples.
PA3-110 has been used successfully in Western blot, immunocytochemistry, and immunohistochemistry procedures. In Western blot analysis of SSTR3 transfected HEK-293 cells this antibody detects a ~60-70 kDa protein representing SSTR3.
The PA3-110 immunogen is a synthetic peptide corresponding to residues C Q(385) E R P P S R V A(393) of human SSTR3.
Target Information
Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: somatostatin receptor; Somatostatin receptor type 3; SS-3-R; SSR-28
Gene Aliases: SS-3-R; SS3-R; SS3R; SSR-28; SSTR3
UniProt ID: (Human) P32745
Entrez Gene ID: (Human) 6753
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
cell-cell signaling
chemical synaptic transmission
spermatogenesis
negative regulation of cell proliferation
hormone-mediated apoptotic signaling pathway
cerebellum development
forebrain development
somatostatin signaling pathway
response to starvation
cellular response to glucocorticoid stimulus
cellular response to estradiol stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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