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Product Details
PA3-207
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the C-terminal amino acids T(417)AGDKASTLSHL(428) of SSTR3
Conjugate
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_10981488
Product Specific Information
PA3-207 detects SSTR3 in rat and mouse samples.
PA3-207 has successfully been used in Western blot, immunofluorescence, immunocytochemical, and immunohistochemical (paraffin) procedures.
The PA3-207 immunogen is a synthetic peptide corresponding to the C-terminal amino acids T(417)AGDKASTLSHL(428) of SSTR3
Target Information
Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: somatostatin receptor; somatostatin receptor 28; somatostatin receptor subtype 3; Somatostatin receptor type 3; SS-3-R; SS3-R; SS3R; SSR-28
Gene Aliases: Smstr-3; Smstr28; Smstr3; sst3; SSTR; Sstr3
UniProt ID: (Mouse) P30935, (Rat) P30936
Entrez Gene ID: (Mouse) 20607, (Rat) 171044
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
neuropeptide signaling pathway
chemical synaptic transmission
negative regulation of cell proliferation
somatostatin signaling pathway
regulation of insulin secretion
cellular response to glucocorticoid stimulus
cellular response to estradiol stimulus
spermatogenesis
cerebellum development
forebrain development
response to starvation
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