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Product Details
15876-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SSX4 Fusion Protein Ag8637 (1-188 aa encoded by BC005325)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MNGDDAFAR RPRDDAQISE KLRKAFDDIA KYFSKKEWEK MKSSEKIVYV YMKLNYEVMT KLGFKVTLPP FMRSKRAADF HGNDFGNDRN HRNQVERPQM TFGSLQRIFP KIMPKKPAEE ENGLKEVPEA SGPQNDGKQL CPPGNPSTLE KINKTSGPKR GKHAWTHRLR ERKQLVVYEE ISDPEEDDE (1-188 aa encoded by BC005325 )
Target Information
SSX4 belongs to the SSX family. It contains 1 KRAB-related domain. SSX4 could act as a modulator of transcription. The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cancer/testis antigen 5.4; CT5.4; MGC119056; MGC12411; Protein SSX4; synovial sarcoma, X breakpoint 4
Gene Aliases: CT5.4; SSX4; SSX4A; SSX4B
UniProt ID: (Human) O60224
Entrez Gene ID: (Human) 6759
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