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Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.
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Protein Aliases: DENN domain-containing protein 2B; DENN/MADD domain containing 2B; HeLa tumor suppression 1; Suppression of tumorigenicity 5 protein
Gene Aliases: 2010004M01Rik; 2610305K15Rik; Denn2b; DENND2B; HTS1; p126; ST5
UniProt ID: (Human) P78524, (Mouse) Q924W7
Entrez Gene ID: (Human) 6764, (Mouse) 76954, (Rat) 308944
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