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Invitrogen
STARD3 Polyclonal Antibody
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FIGURE: 1 / 1
STARD3 Antibody (PA5-96802) in WB
Western blot analysis of STARD3 in extracts of various cell lines. Samples were incubated with STARD3 Polyclonal antibody (Product # PA5-96802) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.
Product Details
PA5-96802
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 170-445 of human STARD3 (NP_0067953)
Conjugate
Form
Liquid
Concentration
0.86 mg/mL
Amount
86 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DFKVLPQEAE EERWYLAAQV AVARGPLLFS GALSEGQFYS PPESFAGSDN ESDEEVAGKK SFSAQEREYI RQGKEATAVV DQILAQEENW KFEKNNEYGD TVYTIEVPFH GKTFILKTFL PCPAELVYQE VILQPERMVL WNKTVTACQI LQRVEDNTLI SYDVSAGAAG GVVSPRDFVN VRRIERRRDR YLSSGIATSH SAKPPTHKYV RGENGPGGFI VLKSASNPRV CTFVWILNTD LKGRLPRYLI HQSLAATMFE FAFHLRQRIS ELGARA; Positive Samples: Jurkat, SKOV3, MCF7, A-549, Mouse lung, Mouse brain, Mouse heart, Rat brain; Cellular Location: Late endosome membrane, Multi-pass membrane protein
Target Information
The steroidogenic acute regulatory (StAR) protein facilitates the movement of cholesterol from the outer to inner mitochondrial membrane in adrenal and gonadal cells, fostering steroid biosynthesis. MLN64 is a 445-amino acid protein of unknown function. When 218 amino-terminal residues of MLN64 are deleted, the resulting N-218 MLN64 has 37% amino acid identity with StAR and 50% of StAR's steroidogenic activity in transfected cells. Bacterially expressed N-218 MLN64 exerts StAR-like activity to promote the transfer of cholesterol from the outer to inner mitochondrial membrane in vitro. The presence of a protease-resistant domain and a protease-sensitive carboxy-terminal domain in N-218 MLN64 is similar to the organization of StAR. However, as MLN64 never enters the mitochondria, the protease-resistant domain of MLN64 cannot be a mitochondrial pause-transfer sequence, as has been proposed for StAR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Metastatic lymph node gene 64 protein; metastatic lymph node protein 64; MLN 64; Protein CAB1; Protein ES 64; Protein MLN 64; StAR-related lipid transfer (START) domain containing 3; StAR-related lipid transfer protein 3; StARD3; START domain containing 3; START domain-containing protein 3; steroidogenic acute regulatory protein related; unnamed protein product
Gene Aliases: CAB1; Es64; MLN64; STARD3
UniProt ID: (Human) Q14849, (Mouse) Q61542
Entrez Gene ID: (Human) 10948, (Mouse) 59045, (Rat) 363675
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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