FIGURE: 1 / 20
This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human STAT5B.
Immunogen sequence: MAVWIQAQQ LQGEALHQMQ ALYGQHFPIE VRHYLSQWIE SQAWDSVDLD NPQENIKATQ LLEGLVQELQ KKAEHQVGED GFLLKIKLGH YATQLQNTYD RCPMELVRCI RHILYNEQRL VREANNGSSP AGSLADAMSQ KHLQINQTFE ELRLVTQDTE NELKKLQQTQ EYFIIQYQES LRIQAQFGPL AQLSPQERLS RETALQQKQV SLEAWLQREA QTLQQYRVEL AEKHQKTLQL LRKQQTIILD DELIQWKRRQ QLAGNGGPPE GSLDVLQSWC EKLAEIIWQN RQQIRRAEHL CQQLPIPGPV EEMLAEVNAT ITDIISALVT STFIIEKQPP QVLKTQTKFA AT (1-351 aa encoded by BC020868)
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Signal transducer and activator of transcription 5B; STA5B; STAT; transcription factor STAT5B
Gene Aliases: STAT5; STAT5B
UniProt ID: (Human) P51692
Entrez Gene ID: (Human) 6777
Molecular Function: DNA-binding transcription factor