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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 15 amino acid peptide from internal region of human STEAP2.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
In IHC applications, antigen retrieval using a citrate buffer (pH 6.0) is recommended.
The six-transmembrane epithelial antigen of prostate 2 (STEAP2) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 3 and STEAP4), STEAP2 promotes both iron and copper reduction. STEAP2 expression in transfected cells also correlated with iron or copper uptake, suggesting that the STEAP family of proteins may function to stimulate iron and copper uptake. STEAP2 is widely expressed in many tissues in the plasma membrane, but is most highly expressed in prostate. At least three isoforms of STEAP2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
IPCA1; metalloreductase STEAP2; PCANAP1; prostate cancer associated protein 1; prostate cancer-associated protein 1; protein up-regulated in metastatic prostate cancer; protein upregulated in metastatic prostate cancer; PUMPCn; six transmembrane; six transmembrane epithelial antigen of prostate 2; six transmembrane epithelial antigen of the prostate 2; six-transmembrane epithelial antigen of prostate 2; SixTransMembrane Protein of Prostate 1; STAMP1; STEAP family member 2, metalloreductase; STMP
IPCA1; PCANAP1; PUMPCn; STAMP1; STEAP2; STMP; UNQ6507/PRO23203