Search
Invitrogen
STK38 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 2
STK38 Antibody (PA5-76351) in IHC (P)
Immunohistochemistry analysis of STK38 in 4% Paraformaldehyde-fixed and paraffin-embedded mouse embryo tissue. Samples were incubated with STK38 polyclonal antibody (Product # PA5-76351) using a dilution of 1:200, overnight at 4°C. Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15 min. Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min. Blocking buffer (normal goat seru... View More
Product Details
PA5-76351
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human STK38: 31-130.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
STK38 (also known as NDR) or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins. Fas and TNFα receptor stimulation activates human STK38 by promoting phosphorylation at the hydrophobic motif. NDR acts as a novel pro-apoptotic kinase, and is a key member of the RASSF1A/MST1 signaling cascade. STK38 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells. STK38 is incorporated into the HIV-1 particles and is cleaved by the HIV-1 protease. STK38-driven centrosome duplication requires Cdk2 activity, and Cdk2-induced centrosome amplification is affected upon reduction of STK38 activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Ndr Ser/Thr kinase-like protein; NDR1 protein kinase; Nuclear Dbf2-related kinase 1; Serine/threonine-protein kinase 38; stk38; unnamed protein product
Gene Aliases: 5830476G13Rik; 9530097A09Rik; AA617404; NDR; NDR1; STK38
UniProt ID: (Human) Q15208, (Mouse) Q91VJ4
Entrez Gene ID: (Human) 11329, (Mouse) 106504, (Rat) 361813
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
mitogen-activated protein kinase kinase kinase binding
cadherin binding
metal ion binding
protein serine kinase activity
ubiquitin-like protein reader activity
histone reader activity
UFM1-modified protein reader activity
transferase activity, transferring phosphorus-containing groups
molecular_function
non-receptor serine/threonine protein kinase
DNA damage checkpoint
chromatin organization
protein phosphorylation
cellular response to DNA damage stimulus
negative regulation of metabolic process
intracellular signal transduction
protein modification process
negative regulation of MAP kinase activity
postsynapse organization
cellular protein modification process
phosphorylation
biological_process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support