Proteintech

STMN2 Polyclonal Antibody

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STMN2 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of SH-SY5Y cells using 10586-1-AP (STMN2 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

STMN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human medulloblastoma tissue slide using 10586-1-AP (STMN2 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

STMN2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA)) — Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using (Product # 10586-1-AP) (STMN2 antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

STMN2 Antibody in Western Blot (WB) — Mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with 10586-1-AP (STMN2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

STMN2 Antibody in Immunoprecipitation (IP) — IP result of anti-STMN2 (IP:10586-1-AP, 3ug; Detection:10586-1-AP 1:1000) with mouse brain tissue lysate 9500ug.

Product Details

10586-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

STMN2 Fusion Protein Ag0929 (1-179 aa encoded by BC006302)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

Immunogen sequence: MAKTAMAYK EKMKELSMLS LICSCFYPEP RNINIYTYDD MEVKQINKRA SGQAFELILK PPSPISEAPR TLASPKKKDL SLEEIQKKLE AAEERRKSQE AQVLKQLAEK REHEREVLQK ALEENNNFSK MAEEKLILKM EQIKENREAN LAAIIERLQE KERHAAEVRR NKELQVELSG (1-179 aa encoded by BC006302)

Target Information

STMN2, also known as SCG-10, is a neuronal growth-associated protein that shares significant amino acid sequence similarity with the phosphoprotein stathmin. STMN2 may play a role in neuronal differentiation, and in modulating membrane interaction with the cytoskeleton during neurite outgrowth. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Atypical TDP-43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP.

Brain pathology (Zurich, Switzerland)

Cooper-Knock J,Julian TH,Feneberg E,Highley JR,Sidra M,Turner MR,Talbot K,Ansorge O,Allen SP,Moll T,Shelkovnikova T,Castelli L,Hautbergue GM,Hewitt C,Kirby J,Wharton SB,Mead RJ,Shaw PJ

Sun Jan 01 00:00:00 EST 2023

Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons.

Neurobiology of disease

Alexandris AS,Ryu J,Rajbhandari L,Harlan R,McKenney J,Wang Y,Aja S,Graham D,Venkatesan A,Koliatsos VE

Thu Sep 01 00:00:00 EDT 2022

Atg7 Knockout Alleviated the Axonal Injury of Neuro-2a Cells Induced by Tri-Ortho-Cresyl Phosphate.

Neurotoxicity research

Zhang C,Kang K,Chen Y,Shan S,Xie K,Song F

Sun Aug 01 00:00:00 EDT 2021

SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration.

The Journal of cell biology

Ko KW,Milbrandt J,DiAntonio A

Mon Aug 03 00:00:00 EDT 2020

Immunohistochemical validation study of 15-gene biomarker panel predictive of benefit from adjuvant chemotherapy in resected non-small-cell lung cancer: analysis of JBR.10.

ESMO open

Grieve S,Ding K,Moore J,Finniss M,Ray A,Lees M,Hossain F,Murugesan A,Agar J,Acar C,Taylor J,Shepherd FA,Reiman T

Sun Mar 01 00:00:00 EST 2020

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration.

Neurobiology of disease

Loreto A,Hill CS,Hewitt VL,Orsomando G,Angeletti C,Gilley J,Lucci C,Sanchez-Martinez A,Whitworth AJ,Conforti L,Dajas-Bailador F,Coleman MP

Sat Feb 01 00:00:00 EST 2020

Retrograde Ret signaling controls sensory pioneer axon outgrowth.

eLife

Tuttle A,Drerup CM,Marra M,McGraw H,Nechiporuk AV

Mon Sep 02 00:00:00 EDT 2019

Key role of SMN/SYNCRIP and RNA-Motif 7 in spinal muscular atrophy: RNA-Seq and motif analysis of human motor neurons.

Brain : a journal of neurology

Rizzo F,Nizzardo M,Vashisht S,Molteni E,Melzi V,Taiana M,Salani S,Santonicola P,Di Schiavi E,Bucchia M,Bordoni A,Faravelli I,Bresolin N,Comi GP,Pozzoli U,Corti S

Fri Feb 01 00:00:00 EST 2019

A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.

The Journal of cell biology

Feinberg K,Kolaj A,Wu C,Grinshtein N,Krieger JR,Moran MF,Rubin LL,Miller FD,Kaplan DR

Mon Nov 06 00:00:00 EST 2017

A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.

The Journal of cell biology

Feinberg K,Kolaj A,Wu C,Grinshtein N,Krieger JR,Moran MF,Rubin LL,Miller FD,Kaplan DR

Mon Nov 06 00:00:00 EST 2017

Kif1B Interacts with KBP to Promote Axon Elongation by Localizing a Microtubule Regulator to Growth Cones.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Drerup CM,Lusk S,Nechiporuk A

Wed Jun 29 00:00:00 EDT 2016

Kif1B Interacts with KBP to Promote Axon Elongation by Localizing a Microtubule Regulator to Growth Cones.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Drerup CM,Lusk S,Nechiporuk A

Wed Jun 29 00:00:00 EDT 2016

Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells.

ACS chemical biology

Kalwat MA,Huang Z,Wichaidit C,McGlynn K,Earnest S,Savoia C,Dioum EM,Schneider JW,Hutchison MR,Cobb MH

Fri Apr 15 00:00:00 EDT 2016

Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells.

ACS chemical biology

Kalwat MA,Huang Z,Wichaidit C,McGlynn K,Earnest S,Savoia C,Dioum EM,Schneider JW,Hutchison MR,Cobb MH

Fri Apr 15 00:00:00 EDT 2016

Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia.

Neuron

Mukai J,Tamura M,Fénelon K,Rosen AM,Spellman TJ,Kang R,MacDermott AB,Karayiorgou M,Gordon JA,Gogos JA

Wed May 06 00:00:00 EDT 2015

Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia.

Neuron

Mukai J,Tamura M,Fénelon K,Rosen AM,Spellman TJ,Kang R,MacDermott AB,Karayiorgou M,Gordon JA,Gogos JA

Wed May 06 00:00:00 EDT 2015

Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity.

Pain

Kallenborn-Gerhardt W,Hohmann SW,Syhr KM,Schröder K,Sisignano M,Weigert A,Lorenz JE,Lu R,Brüne B,Brandes RP,Geisslinger G,Schmidtko A

Wed Oct 01 00:00:00 EDT 2014

Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity.

Pain

Kallenborn-Gerhardt W,Hohmann SW,Syhr KM,Schröder K,Sisignano M,Weigert A,Lorenz JE,Lu R,Brüne B,Brandes RP,Geisslinger G,Schmidtko A

Wed Oct 01 00:00:00 EDT 2014

Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice.

Pain

Kynast KL,Russe OQ,Möser CV,Geisslinger G,Niederberger E

Fri Mar 01 00:00:00 EST 2013

Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice.

Pain

Kynast KL,Russe OQ,Möser CV,Geisslinger G,Niederberger E

Fri Mar 01 00:00:00 EST 2013

SCG10 is a JNK target in the axonal degeneration pathway.

Proceedings of the National Academy of Sciences of the United States of America

Shin JE,Miller BR,Babetto E,Cho Y,Sasaki Y,Qayum S,Russler EV,Cavalli V,Milbrandt J,DiAntonio A

Wed Dec 26 00:00:00 EST 2012

SCG10 is a JNK target in the axonal degeneration pathway.

Proceedings of the National Academy of Sciences of the United States of America

Shin JE,Miller BR,Babetto E,Cho Y,Sasaki Y,Qayum S,Russler EV,Cavalli V,Milbrandt J,DiAntonio A

Wed Dec 26 00:00:00 EST 2012

CNGA3: a target of spinal nitric oxide/cGMP signaling and modulator of inflammatory pain hypersensitivity.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Heine S,Michalakis S,Kallenborn-Gerhardt W,Lu R,Lim HY,Weiland J,Del Turco D,Deller T,Tegeder I,Biel M,Geisslinger G,Schmidtko A

Wed Aug 03 00:00:00 EDT 2011

CNGA3: a target of spinal nitric oxide/cGMP signaling and modulator of inflammatory pain hypersensitivity.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Heine S,Michalakis S,Kallenborn-Gerhardt W,Lu R,Lim HY,Weiland J,Del Turco D,Deller T,Tegeder I,Biel M,Geisslinger G,Schmidtko A

Wed Aug 03 00:00:00 EDT 2011

CNGA3: a target of spinal nitric oxide/cGMP signaling and modulator of inflammatory pain hypersensitivity.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Heine S,Michalakis S,Kallenborn-Gerhardt W,Lu R,Lim HY,Weiland J,Del Turco D,Deller T,Tegeder I,Biel M,Geisslinger G,Schmidtko A

Wed Aug 03 00:00:00 EDT 2011

Interleukin-6 and neural stem cells: more than gliogenesis.

Molecular biology of the cell

Islam O,Gong X,Rose-John S,Heese K

Thu Jan 01 00:00:00 EST 2009

Interleukin-6 and neural stem cells: more than gliogenesis.

Molecular biology of the cell

Islam O,Gong X,Rose-John S,Heese K

Thu Jan 01 00:00:00 EST 2009

Bioinformatics

Protein Aliases: neuron-specific growth-associated protein; neuronal growth-associated protein (silencer element); Protein SCG10; SGC10; Stathmin-2; stathmin-like 2; superior cervical ganglia, neural specific 10; Superior cervical ganglion-10 protein; superiorcervical ganglia, neural specific 10

Gene Aliases: AI159727; SCG10; SCGN10; Stmb2; STMN2

UniProt ID: (Human) Q93045, (Rat) P21818, (Mouse) P55821

Entrez Gene ID: (Human) 11075, (Rat) 84510, (Mouse) 20257

Function(s)

negative regulation of microtubule depolymerization positive regulation of neuron projection development negative regulation of neuron projection development negative regulation of microtubule polymerization positive regulation of microtubule depolymerization cellular response to nerve growth factor stimulus microtubule depolymerization neuron projection development regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization

Process(es)

protein binding tubulin binding calcium-dependent protein binding

STMN2 Polyclonal Antibody

Product Details

10586-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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