Heparan sulfate proteoglycans act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF1, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules.
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Protein Aliases: Extracellular sulfatase Sulf-1; FLJ30905; FLJ38022; FLJ41750; hSulf-1; sulfatase FP
Gene Aliases: KIAA1077; SULF-1; SULF1
UniProt ID: (Human) Q8IWU6
Entrez Gene ID: (Human) 23213
Molecular Function: hydrolase