Heparan sulfate proteoglycans act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF1, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Extracellular sulfatase Sulf-1; FLJ30905; FLJ38022; FLJ41750; hSulf-1; MSulf-1; RSulfFP1; Sulfatase FP
Gene Aliases: AI467640; AW121680; KIAA1077; mKIAA1077; SULF-1; SULF1
Molecular Function: hydrolase