Sequence of this protein is as follows: MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLISTYPKSG TTWVSQILDM IYQGGDLEKC HRAPIFMRVP FLEFKAPGIP SGMETLKDTP APRLLKTHLP LALLPQTLLD QKVKVVYVAR NAKDVAVSYY HFYHMAKVHP EPGTWDSFLE KFMVGEVSYG SWYQHVQEWW ELSRTHPVLY LFYEDMKENP KREIQKILEF VGHSLPEETV DFVVQHTSFK EMKKNPMTNY TTVPQEFMDH SISPFMRKGM AGDWKTTFTV AQNERFDADY AEKMAGCSLS FRSEL
The soluble sulfotransferases contribute to the elimination of xenobiotics, the activation of procarcinogens and the regulation of hormones by catalyzing the sulfate conjugation of these substances. Members of the three groups comprising this superfamily (namely SULT1, SULT2 and SULT3) show selectivity to certain substrate compounds. SULT1A1 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1), also known as STP or STP1, is a 295 amino acid protein that localizes to the cytoplasm and belongs to the sulfotransferase family. Functioning as a homodimer that is expressed in brain, liver, skin and lung tissue, SULT1A1 catalyzes the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters and, via this catalytic activity, plays a role in the elimination of a variety of compounds from the body. Additionally, SULT1A1 may be involved in the activation of carcinogenic N-hydroxyarylamines, indicating a possible role in carcinogenesis.
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Protein Aliases: aryl sulfotransferase; Aryl sulfotransferase 1; arylsulfotransferase ST1A4; CSPS; HAST1/HAST2; MGC131921; MGC5163; mSTp1; OTTHUMP00000162568; OTTHUMP00000162569; P PST; P PST 1; P-PST 1; phenol sulfotransferase; Phenol sulfotransferase 1; Phenol-sulfating phenol sulfotransferase 1; phenol/aryl sulfotransferase; ST1A1; ST1A3; ST1A4; sulfokinase; Sulfotransferase 1A1; sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; sulfotransferase, phenol preferring 1; Thermostable phenol sulfotransferase; thermostable phenol sulfotransferase1; Ts-PST
Gene Aliases: AI266890; HAST1/HAST2; OK/SW-cl.88; P-PST; PST; ST1A1; ST1A3; STP; STP1; SULT1A1; TSPST1
UniProt ID: (Human) P50225
Molecular Function: transferase