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SULT1E1 Polyclonal Antibody

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SULT1E1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 12522-1-AP ( SULT1E1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

SULT1E1 Antibody in Western Blot (WB) — Human adrenal gland tissue were subjected to SDS PAGE followed by western blot with 12522-1-AP (SULT1E1 antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours.

SULT1E1 Antibody in Immunoprecipitation (IP) — IP result of anti-SULT1E1 (IP:12522-1-AP, 4ug; Detection:12522-1-AP 1:400) with mouse liver tissue lysate 4000ug.

Product Details

12522-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SULT1E1 Fusion Protein Ag3216 (1-294 aa encoded by BC027956)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.38 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

This antibody detected a major band around 35 kDa in lysates of mouse kidney and human liver.

Immunogen sequence: MNSELDYYE KFEEVHGILM YKDFVKYWDN VEAFQARPDD LVIATYPKSG TTWVSEIVYM IYKEGDVEKC KEDVIFNRIP FLECRKENLM NGVKQLDEMN SPRIVKTHLP PELLPASFWE KDCKIIYLCR NAKDVAVSFY YFFLMVAGHP NPGSLPEFVE KFMQGQVPYG SWYKHVKSWW EKGKSPRVLF LFYEDLKEDI RKEVIKLIHF LERKPSEELV DRIIHHTSFQ EMKNNPSTNY TTLPDEIMNQ KLSPFMRKGI TGDWKNHFTV ALNEKFDKHY EQQMKESTLK FRTEI (1-294 aa encoded by BC027956)

Target Information

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Naringenin in Si-Ni-San formula inhibits chronic psychological stress-induced breast cancer growth and metastasis by modulating estrogen metabolism through FXR/EST pathway.

Journal of advanced research

Zhang J,Wang N,Zheng Y,Yang B,Wang S,Wang X,Pan B,Wang Z

Mon May 01 00:00:00 EDT 2023

Naringenin in Si-Ni-San formula inhibits chronic psychological stress-induced breast cancer growth and metastasis by modulating estrogen metabolism through FXR/EST pathway.

Journal of advanced research

Zhang J,Wang N,Zheng Y,Yang B,Wang S,Wang X,Pan B,Wang Z

Mon May 01 00:00:00 EDT 2023

PXR phosphorylated at Ser350 transduces a glucose signal to repress the estrogen sulfotransferase gene in human liver cells and fasting signal in mouse livers.

Biochemical pharmacology

Hu H,Yokobori K,Negishi M

Thu Oct 01 00:00:00 EDT 2020

RORα phosphorylation by casein kinase 1α as glucose signal to regulate estrogen sulfation in human liver cells.

The Biochemical journal

Hu H,Negishi M

Wed Sep 30 00:00:00 EDT 2020

Inhibition of Estrogen Sulfotransferase (SULT1E1/EST) Ameliorates Ischemic Acute Kidney Injury in Mice.

Journal of the American Society of Nephrology : JASN

Silva Barbosa AC,Zhou D,Xie Y,Choi YJ,Tung HC,Chen X,Xu M,Gibbs RB,Poloyac SM,Liu S,Yu Y,Luo J,Liu Y,Xie W

Wed Jul 01 00:00:00 EDT 2020

Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver.

Scientific reports

Yi M,Fashe M,Arakawa S,Moore R,Sueyoshi T,Negishi M

Thu Mar 19 00:00:00 EDT 2020

Hepatic Estrogen Sulfotransferase Distantly Sensitizes Mice to Hemorrhagic Shock-Induced Acute Lung Injury.

Endocrinology

Xie Y,Barbosa ACS,Xu M,Oberly PJ,Ren S,Gibbs RB,Poloyac SM,Song WC,Fan J,Xie W

Wed Jan 01 00:00:00 EST 2020

Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Sun Z,Liu Y,Yu F,Xu Y,Yanli L,Liu N

Mon Jul 01 00:00:00 EDT 2019

Sulfotransferase 4A1 Increases Its Expression in Mouse Neurons as They Mature.

Drug metabolism and disposition: the biological fate of chemicals

Hashiguchi T,Shindo S,Chen SH,Hong JS,Negishi M

Fri Jun 01 00:00:00 EDT 2018

Sulfotransferase 4A1 Increases Its Expression in Mouse Neurons as They Mature.

Drug metabolism and disposition: the biological fate of chemicals

Hashiguchi T,Shindo S,Chen SH,Hong JS,Negishi M

Fri Jun 01 00:00:00 EDT 2018

Farnesoid X receptor regulates SULT1E1 expression through inhibition of PGC1α binding to HNF4α.

Biochemical pharmacology

Wang S,Yuan X,Lu D,Guo L,Wu B

Fri Dec 01 00:00:00 EST 2017

Farnesoid X receptor regulates SULT1E1 expression through inhibition of PGC1α binding to HNF4α.

Biochemical pharmacology

Wang S,Yuan X,Lu D,Guo L,Wu B

Fri Dec 01 00:00:00 EST 2017

Sex- and Tissue-Specific Role of Estrogen Sulfotransferase in Energy Homeostasis and Insulin Sensitivity.

Endocrinology

Garbacz WG,Jiang M,Xu M,Yamauchi J,Dong HH,Xie W

Wed Nov 01 00:00:00 EDT 2017

Sex- and Tissue-Specific Role of Estrogen Sulfotransferase in Energy Homeostasis and Insulin Sensitivity.

Endocrinology

Garbacz WG,Jiang M,Xu M,Yamauchi J,Dong HH,Xie W

Wed Nov 01 00:00:00 EDT 2017

Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer.

Oncology letters

Mungenast F,Aust S,Vergote I,Vanderstichele A,Sehouli J,Braicu E,Mahner S,Castillo-Tong DC,Zeillinger R,Thalhammer T

Thu Jun 01 00:00:00 EDT 2017

Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer.

Oncology letters

Mungenast F,Aust S,Vergote I,Vanderstichele A,Sehouli J,Braicu E,Mahner S,Castillo-Tong DC,Zeillinger R,Thalhammer T

Thu Jun 01 00:00:00 EDT 2017

Resveratrol and its methoxy derivatives modulate the expression of estrogen metabolism enzymes in breast epithelial cells by AhR down-regulation.

Molecular and cellular biochemistry

Licznerska B,Szaefer H,Wierzchowski M,Sobierajska H,Baer-Dubowska W

Sun Jan 01 00:00:00 EST 2017

Resveratrol and its methoxy derivatives modulate the expression of estrogen metabolism enzymes in breast epithelial cells by AhR down-regulation.

Molecular and cellular biochemistry

Licznerska B,Szaefer H,Wierzchowski M,Sobierajska H,Baer-Dubowska W

Sun Jan 01 00:00:00 EST 2017

Oestrogen sulfotransferase ablation sensitizes mice to sepsis.

Nature communications

Chai X,Guo Y,Jiang M,Hu B,Li Z,Fan J,Deng M,Billiar TR,Kucera HR,Gaikwad NW,Xu M,Lu P,Yan J,Fu H,Liu Y,Yu L,Huang M,Zeng S,Xie W

Mon Aug 10 00:00:00 EDT 2015

Oestrogen sulfotransferase ablation sensitizes mice to sepsis.

Nature communications

Chai X,Guo Y,Jiang M,Hu B,Li Z,Fan J,Deng M,Billiar TR,Kucera HR,Gaikwad NW,Xu M,Lu P,Yan J,Fu H,Liu Y,Yu L,Huang M,Zeng S,Xie W

Mon Aug 10 00:00:00 EDT 2015

Estrogen Sulfotransferase Is an Oxidative Stress-responsive Gene That Gender-specifically Affects Liver Ischemia/Reperfusion Injury.

The Journal of biological chemistry

Guo Y,Hu B,Huang H,Tsung A,Gaikwad NW,Xu M,Jiang M,Ren S,Fan J,Billiar TR,Huang M,Xie W

Fri Jun 05 00:00:00 EDT 2015

Estrogen Sulfotransferase Is an Oxidative Stress-responsive Gene That Gender-specifically Affects Liver Ischemia/Reperfusion Injury.

The Journal of biological chemistry

Guo Y,Hu B,Huang H,Tsung A,Gaikwad NW,Xu M,Jiang M,Ren S,Fan J,Billiar TR,Huang M,Xie W

Fri Jun 05 00:00:00 EDT 2015

Effects of PPAR-α agonist and IGF-1 on estrogen sulfotransferase in human vascular endothelial and smooth muscle cells.

Molecular medicine reports

Li Y,Xu Y,Li X,Qin Y,Hu R

Mon Jul 01 00:00:00 EDT 2013

Effects of PPAR-α agonist and IGF-1 on estrogen sulfotransferase in human vascular endothelial and smooth muscle cells.

Molecular medicine reports

Li Y,Xu Y,Li X,Qin Y,Hu R

Mon Jul 01 00:00:00 EDT 2013

Estrogen sulfotransferase (SULT1E1) regulates inflammatory response and lipid metabolism of human endothelial cells via PPARγ.

Molecular and cellular endocrinology

Xu Y,Yang X,Wang Z,Li M,Ning Y,Chen S,Yin L,Li X

Tue Apr 30 00:00:00 EDT 2013

Estrogen sulfotransferase (SULT1E1) regulates inflammatory response and lipid metabolism of human endothelial cells via PPARγ.

Molecular and cellular endocrinology

Xu Y,Yang X,Wang Z,Li M,Ning Y,Chen S,Yin L,Li X

Tue Apr 30 00:00:00 EDT 2013

Estrogen sulfotransferase (SULT1E1) regulates inflammatory response and lipid metabolism of human endothelial cells via PPARγ.

Molecular and cellular endocrinology

Xu Y,Yang X,Wang Z,Li M,Ning Y,Chen S,Yin L,Li X

Tue Apr 30 00:00:00 EDT 2013

Estrogen sulfotransferase (SULT1E1) regulates inflammatory response and lipid metabolism of human endothelial cells via PPARγ.

Molecular and cellular endocrinology

Xu Y,Yang X,Wang Z,Li M,Ning Y,Chen S,Yin L,Li X

Tue Apr 30 00:00:00 EDT 2013

Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers.

Cancer science

Xu Y,Liu X,Guo F,Ning Y,Zhi X,Wang X,Chen S,Yin L,Li X

Fri Jun 01 00:00:00 EDT 2012

Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers.

Cancer science

Xu Y,Liu X,Guo F,Ning Y,Zhi X,Wang X,Chen S,Yin L,Li X

Fri Jun 01 00:00:00 EDT 2012

Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers.

Cancer science

Xu Y,Liu X,Guo F,Ning Y,Zhi X,Wang X,Chen S,Yin L,Li X

Fri Jun 01 00:00:00 EDT 2012

Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers.

Cancer science

Xu Y,Liu X,Guo F,Ning Y,Zhi X,Wang X,Chen S,Yin L,Li X

Fri Jun 01 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: EST-1; EST-2; EST-3; EST-6; Estrogen sulfotransferase; Estrogen sulfotransferase, isoform 3; estrogen sulfotransferase, testis isoform; Estrone sulfotransferase; ST1E1; Sulfotransferase 1E1; sulfotransferase family 1E, estrogen-preferring, member 1; sulfotransferase, estrogen preferring; Sulfotransferase, estrogen-preferring

Gene Aliases: EST; EST-1; ST1E1; STE; SULT1E1

UniProt ID: (Human) P49888, (Rat) P49889

Entrez Gene ID: (Human) 6783, (Mouse) 20860, (Rat) 360268

Molecular Function: transferase

Function(s)

steroid metabolic process estrogen metabolic process positive regulation of fat cell differentiation 3'-phosphoadenosine 5'-phosphosulfate metabolic process sulfation female pregnancy metabolic process

Process(es)

SULT1E1 Polyclonal Antibody

Product Details

12522-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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