Sequence of this protein is as follows: MGTLLGLGAV LAYQDHRCRA AQESTHIYTK EEVSSHTSPE TGIWVTLGSE VFDVTEFVDL HPGGPSKLML AAGGPLEPFW ALYAVHNQSH VRELLAQYKI GELNPEDKVA PTVETSDPYA DDPVRHPALK VNSQRPFNAE PPPELLTENY ITPNPIFFTR NHLPVPNLDP DTYRLHVVGA PGGQSLSLSL DDLHNFPRYE ITVTLQCAGN RRSEMTQVKE VKGLEWRTGA ISTARWAGAR LCDVLAQAGH QLCETEAHVC FEGLDSDPTG TAYGASIPLA RAMDPEAEVL LAYEMNGQPL PRDHGFPVRV VVPGVVGARH VKWLGRVSVQ PEESYSHWQR RDYKGFSPSV DWETVDFDSA PSIQELPVQS AITEPRDGET VESGEVTIKG YAWSGGGRAV IRVDVSLDGG LTWQVAKLDG EEQRPRKAWA WRLWQLKAPV PAGQKELNIV CKAVDDGYNV QPDTVAPIWN LRGVLSNAWH RVHVYVSP
Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins.
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Protein Aliases: Sulfite oxidase, mitochondrial
Gene Aliases: SO; SUOX