Proteintech

SURVIVIN Polyclonal Antibody

SURVIVIN Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 16

SURVIVIN Antibody (10508-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed MCF-7 cells using SURVIVIN antibody (Product # 10508-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

SURVIVIN Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SURVIVIN Antibody in Flow Cytometry (Flow)

SURVIVIN Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10508-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 102 publications 102 publications

Immunohistochemistry (IHC)

View 12 publications 12 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:400

Immunocytochemistry (ICC/IF)

1:200

View 4 publications 4 publications

Flow Cytometry (Flow)

Assay-dependent

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Hamster, Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SURVIVIN Fusion Protein Ag0788 (1-142 aa encoded by BC008718)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MGAPTLPPA WQPFLKDHRI STFKNWPFLE GCACTPERMA EAGFIHCPTE NEPDLAQCFF CFKELEGWEP DDDPIEEHKK HSSGCAFLSV KKQFEELTLG EFLKLDRERA KNKIAKETNN KKKEFEETAK KVRRAIEQLA AMD (1-142 aa encoded by BC008718)

Target Information

Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family. The IAPs are involved in multiple cell functions such as cell signaling, cell division, metabolism, and exhibits differential expression in nearly all human cancers, but not in most normal tissues. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but the Survivin gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of survivin’s gene expression. Survivin is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. Survivin may counteract a default induction of apoptosis in G2/M phase. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ATB^0,+-targeted nanoparticles initiate autophagy suppression to overcome chemoresistance for enhanced colorectal cancer therapy.

International journal of pharmaceutics

Chen Z,Chen H,Huang L,Duan B,Dai S,Cai W,Sun M,Jiang Z,Lu R,Jiang Y,Jiang X,Zheng H,Yao Q,Kim K,Lin G,Xie C,Chu M,Chen R,Kou L

Sun Jun 25 00:00:00 UTC 2023

δ-Catenin Requirement in Keratinocyte Proliferation and DNA Repair Identifies a Therapeutic Target for Photoaging.

The Journal of investigative dermatology

Shen Y,Kim K,Zhu Z,Zhang S,Jiang M,Liu Z,Zheng Y,Li X,Jin L,Cong W

Sun Jan 01 00:00:00 UTC 2023

TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Wu M,Jin Q,Xu X,Fan J,Chen W,Miao M,Gu R,Zhang S,Guo Y,Huang S,Zhang Y,Zhang A,Jia Z

Fri Sep 01 00:00:00 UTC 2023

TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Wu M,Jin Q,Xu X,Fan J,Chen W,Miao M,Gu R,Zhang S,Guo Y,Huang S,Zhang Y,Zhang A,Jia Z

Fri Sep 01 00:00:00 UTC 2023

TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Wu M,Jin Q,Xu X,Fan J,Chen W,Miao M,Gu R,Zhang S,Guo Y,Huang S,Zhang Y,Zhang A,Jia Z

Fri Sep 01 00:00:00 UTC 2023

TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Wu M,Jin Q,Xu X,Fan J,Chen W,Miao M,Gu R,Zhang S,Guo Y,Huang S,Zhang Y,Zhang A,Jia Z

Fri Sep 01 00:00:00 UTC 2023

TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Wu M,Jin Q,Xu X,Fan J,Chen W,Miao M,Gu R,Zhang S,Guo Y,Huang S,Zhang Y,Zhang A,Jia Z

Fri Sep 01 00:00:00 UTC 2023

TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Wu M,Jin Q,Xu X,Fan J,Chen W,Miao M,Gu R,Zhang S,Guo Y,Huang S,Zhang Y,Zhang A,Jia Z

Fri Sep 01 00:00:00 UTC 2023

Identification of a prognostic biomarker predicting biochemical recurrence and construction of a novel nomogram for prostate cancer.

Frontiers in oncology

Yu Z,Chao H,Xu F,Deng H,Deng L,Song Z,Zeng T

Fri Apr 21 00:00:00 UTC 2023

Histone H3K27 methyltransferase EZH2 regulates apoptotic and inflammatory responses in sepsis-induced AKI.

Theranostics

Li B,Xia Y,Mei S,Ye Z,Song B,Yan X,Lin F,Rao T,Yu W,Mei C,Lv J,Wu M,Mao Z,Zhou X,Cheng F

Tue Apr 18 00:00:00 UTC 2023

Histone H3K27 methyltransferase EZH2 regulates apoptotic and inflammatory responses in sepsis-induced AKI.

Theranostics

Li B,Xia Y,Mei S,Ye Z,Song B,Yan X,Lin F,Rao T,Yu W,Mei C,Lv J,Wu M,Mao Z,Zhou X,Cheng F

Tue Apr 18 00:00:00 UTC 2023

Histone H3K27 methyltransferase EZH2 regulates apoptotic and inflammatory responses in sepsis-induced AKI.

Theranostics

Li B,Xia Y,Mei S,Ye Z,Song B,Yan X,Lin F,Rao T,Yu W,Mei C,Lv J,Wu M,Mao Z,Zhou X,Cheng F

Tue Apr 18 00:00:00 UTC 2023

Histone H3K27 methyltransferase EZH2 regulates apoptotic and inflammatory responses in sepsis-induced AKI.

Theranostics

Li B,Xia Y,Mei S,Ye Z,Song B,Yan X,Lin F,Rao T,Yu W,Mei C,Lv J,Wu M,Mao Z,Zhou X,Cheng F

Tue Apr 18 00:00:00 UTC 2023

5‑Aminolevurinic acid inhibits the proliferation of bladder cancer cells by activating heme synthesis.

Oncology reports

Nakai Y,Tatsumi Y,Hori S,Morizawa Y,Iida K,Onishi K,Miyake M,Oda Y,Owari T,Fujii T,Onishi S,Tanaka N,Fujimoto K

Sat Oct 01 00:00:00 UTC 2022

Proteomic analysis reveals that Xbp1s promotes hypoxic pulmonary hypertension through the p-JNK MAPK pathway.

Journal of cellular physiology

Jiang H,Niu Y,He Y,Li X,Xu Y,Liu X

Tue Mar 01 00:00:00 UTC 2022

DEC1 promotes progression of Helicobacter pylori-positive gastric cancer by regulating Akt/NF-κB pathway.

Journal of cellular and molecular medicine

Jia Y,Liu Y,Zhu J,Liu L,Ma X,Liu D,Han S,Zhang L,Ling ZQ,Wang Y

Fri Apr 01 00:00:00 UTC 2022

CDK12 orchestrates super-enhancer-associated CCDC137 transcription to direct hepatic metastasis in colorectal cancer.

Clinical and translational medicine

Dai W,Wu J,Peng X,Hou W,Huang H,Cheng Q,Liu Z,Luyten W,Schoofs L,Zhou J,Liu S

Sat Oct 01 00:00:00 UTC 2022

Amination Potentially Augments the Ameliorative Effect of Curcumin on Inhibition of the IL-6/Stat3/c-Myc Pathway and Gut Microbial Modulation in Colitis-Associated Tumorigenesis.

Journal of agricultural and food chemistry

Koh YC,Tsai YW,Lee PS,Nagabhushanam K,Ho CT,Pan MH

Wed Nov 23 00:00:00 UTC 2022

miR-126-5p enhances radiosensitivity of lung adenocarcinoma cells by inhibiting EZH2 via the KLF2/BIRC axis.

Journal of cellular and molecular medicine

Han F,Huang D,Meng J,Chu J,Wang M,Chen S

Sun May 01 00:00:00 UTC 2022

miR-126-5p enhances radiosensitivity of lung adenocarcinoma cells by inhibiting EZH2 via the KLF2/BIRC axis.

Journal of cellular and molecular medicine

Han F,Huang D,Meng J,Chu J,Wang M,Chen S

Sun May 01 00:00:00 UTC 2022

Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease.

Respiratory research

Zhan Y,Chen J,Wu J,Gu Y,Huang Q,Deng Z,Chen S,Wu X,Lv Y,Zeng Z,Xie J

Thu May 12 00:00:00 UTC 2022

Hispolon Methyl Ether, a Hispolon Analog, Suppresses the SRC/STAT3/Survivin Signaling Axis to Induce Cytotoxicity in Human Urinary Bladder Transitional Carcinoma Cell Lines.

International journal of molecular sciences

Kuo MY,Yang WT,Ho YJ,Chang GM,Chang HH,Hsu CY,Chang CC,Chen YH

Wed Dec 21 00:00:00 UTC 2022

Survivin suppression heightens BZML-induced mitotic catastrophe to overcome multidrug resistance by removing therapy-induced senescent A549/Taxol cells.

Biochimica et biophysica acta. Molecular cell research

Bai Z,Zhou Y,Ye X,Li Y,Peng Y,Guan Q,Zhang W,Ma L

Tue Feb 01 00:00:00 UTC 2022

Survivin suppression heightens BZML-induced mitotic catastrophe to overcome multidrug resistance by removing therapy-induced senescent A549/Taxol cells.

Biochimica et biophysica acta. Molecular cell research

Bai Z,Zhou Y,Ye X,Li Y,Peng Y,Guan Q,Zhang W,Ma L

Tue Feb 01 00:00:00 UTC 2022

Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK signaling pathways in hypoxic pulmonary hypertension.

Respiratory research

Guo M,Zhang M,Cao X,Fang X,Li K,Qin L,He Y,Zhao J,Xu Y,Liu X,Li X

Tue Jan 11 00:00:00 UTC 2022

The N6-Methylandenosine-Related Gene BIRC5 as a Prognostic Biomarker Correlated With Cell Migration and Immune Cell Infiltrates in Low Grade Glioma.

Frontiers in molecular biosciences

Jiang X,Shi Y,Chen X,Xu H,Huang X,Li L,Pu J

Tue Mar 22 00:00:00 UTC 2022

Developing and Validating an Autophagy Gene-Set-Based Prognostic Signature in Hepatocellular Carcinoma Patients.

International journal of general medicine

Zhang J,Zhao J,Wei S,Huang P,Tu X,Su G,Gan Y,Gong W,Xiang B

Tue Dec 06 00:00:00 UTC 2022

Chidamide and mitomycin C exert synergistic cytotoxic effects against bladder cancer cells in vitro and suppress tumor growth in a rat bladder cancer model.

Cancer letters

Wang SC,Yu CY,Wu YC,Chang YC,Chen SL,Sung WW

Fri Apr 01 00:00:00 UTC 2022

Mechanism of HSP90 Inhibitor in the Treatment of DSS-induced Colitis in Mice by Inhibiting MAPK Pathway and Synergistic Effect of Compound Sophora Decoction.

Current pharmaceutical design

Yuan Y,Wu H,Shuai B,Liu C,Zhu F,Gao F,Wei C,Fan H

Fri Jan 06 00:00:00 UTC 2023

Inhibition of STAT3^Y705 phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells.

Cell death discovery

Guo H,Xiao Y,Yuan Z,Yang X,Chen J,Chen C,Wang M,Xie L,Chen Q,Tong Y,Zhang Q,Bai Y

Mon Mar 14 00:00:00 UTC 2022

Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse.

Cellular and molecular life sciences : CMLS

Li H,Chen H,Zhang X,Qi Y,Wang B,Cui Y,Ren J,Zhao Y,Chen Y,Zhu T,Wang Y,Yao L,Guo Y,Zhu H,Li Y,Situ C,Guo X

Fri Aug 05 00:00:00 UTC 2022

Artesunate Suppresses the Growth of Lung Cancer Cells by Downregulating the AKT/Survivin Signaling Pathway.

BioMed research international

Zhang W,Ning N,Huang J

Fri Apr 08 00:00:00 UTC 2022

Five-gene signature associating with Gleason score serve as novel biomarkers for identifying early recurring events and contributing to early diagnosis for Prostate Adenocarcinoma.

Journal of Cancer

Zhang L,Li Y,Wang X,Ping Y,Wang D,Cao Y,Dai Y,Liu W,Tao Z

Sat Nov 11 00:00:00 UTC 2023

Mechanistic study of lncRNA UCA1 promoting growth and cisplatin resistance in lung adenocarcinoma.

Cancer cell international

Fu J,Pan J,Yang X,Zhang Y,Shao F,Chen J,Huang K,Wang Y

Mon Sep 20 00:00:00 UTC 2021

Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.

Frontiers in oncology

Zhu X,Li R,Wang C,Zhou S,Fan Y,Ma S,Gao D,Gai N,Yang J

Tue Aug 03 00:00:00 UTC 2021

VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway.

Scientific reports

Li H,Dang C,Tai X,Xue L,Meng Y,Ma S,Zhang J

Thu Jul 22 00:00:00 UTC 2021

Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells.

International journal of biological sciences

Liu Y,Shi C,He Z,Zhu F,Wang M,He R,Zhao C,Shi X,Zhou M,Pan S,Gao Y,Li X,Qin R

Mon Jan 03 00:00:00 UTC 2022

Elevated Serum FGG Levels Prognosticate and Promote the Disease Progression in Prostate Cancer.

Frontiers in genetics

Peng HH,Wang JN,Xiao LF,Yan M,Chen SP,Wang L,Yang K

Tue May 18 00:00:00 UTC 2021

Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells.

Cell death & disease

Huangfu J,Hao C,Wei Z,Wormstone IM,Yan H,Fan X

Fri Apr 09 00:00:00 UTC 2021

Iguratimod-encapsulating PLGA-NPs induce human multiple myeloma cell death via reactive oxygen species and Caspase-dependent signalling.

International immunopharmacology

Wang F,Younis M,Luo Y,Zhang L,Yuan L

Tue Jun 01 00:00:00 UTC 2021

Long noncoding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple-negative breast cancer.

Cell death & disease

Zhang X,Li F,Zhou Y,Mao F,Lin Y,Shen S,Li Y,Zhang S,Sun Q

Fri Jun 18 00:00:00 UTC 2021

Periplocymarin Induced Colorectal Cancer Cells Apoptosis Via Impairing PI3K/AKT Pathway.

Frontiers in oncology

Cheng Y,Wang G,Zhao L,Dai S,Han J,Hu X,Zhou C,Wang F,Ma H,Li B,Meng Z

Wed Dec 15 00:00:00 UTC 2021

Regulation of survivin protein stability by USP35 is evolutionarily conserved.

Biochemical and biophysical research communications

Wang W,Lin H,Zheng E,Hou Z,Liu Y,Huang W,Chen D,Feng J,Li J,Li L

Fri Oct 15 00:00:00 UTC 2021

α5-nAChR and survivin: Two potential biological targets in lung adenocarcinoma.

Journal of cellular physiology

Zhang Y,Sun Y,Jia Y,Zhang Q,Zhu P,Ma X

Mon Mar 01 00:00:00 UTC 2021

TRB3 mediates vascular remodeling by activating the MAPK signaling pathway in hypoxic pulmonary hypertension.

Respiratory research

Cao X,Fang X,Guo M,Li X,He Y,Xie M,Xu Y,Liu X

Tue Dec 14 00:00:00 UTC 2021

Microenvironment Analysis of Prognosis and Molecular Signature of Immune-Related Genes in Lung Adenocarcinoma.

Oncology research

Ling B,Huang Z,Huang S,Qian L,Li G,Tang Q

Tue Mar 16 00:00:00 UTC 2021

Discovering and Characterizing of Survivin Dominant Negative Mutants With Stronger Pro-apoptotic Activity on Cancer Cells and CSCs.

Frontiers in oncology

Guo W,Ma X,Fu Y,Liu C,Liu Q,Hu F,Miao H,Zhang T,Liu Y,Han MH,You F,Yang Y,Zheng W

Wed Apr 21 00:00:00 UTC 2021

miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5.

Cancer cell international

Yuan C,Su Z,Liao S,Li D,Zhou Z,Wang Y,Quan M,Zeng L,Lv C,Shen C,Gong W,Wu J,Chen X,Hu W,Lv X,Si W,Yu X

Wed Jul 21 00:00:00 UTC 2021

miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5.

Cancer cell international

Yuan C,Su Z,Liao S,Li D,Zhou Z,Wang Y,Quan M,Zeng L,Lv C,Shen C,Gong W,Wu J,Chen X,Hu W,Lv X,Si W,Yu X

Wed Jul 21 00:00:00 UTC 2021

Establishment of a hTfR mAb-functionalized HPPS theranostic nanoplatform.

Nanotheranostics

He Q,Guo Z,Fu M,Tang H,Zhu H,Shen G,He Y,Lei P

Fri Apr 16 00:00:00 UTC 2021

Pulp stem cells with hepatocyte growth factor overexpression exhibit dual effects in rheumatoid arthritis.

Stem cell research & therapy

Dong X,Kong F,Liu C,Dai S,Zhang Y,Xiao F,Zhang H,Wu CT,Wang H

Wed Jun 10 00:00:00 UTC 2020

USP10 Promotes Proliferation of Hepatocellular Carcinoma by Deubiquitinating and Stabilizing YAP/TAZ.

Cancer research

Zhu H,Yan F,Yuan T,Qian M,Zhou T,Dai X,Cao J,Ying M,Dong X,He Q,Yang B

Mon Jun 01 00:00:00 UTC 2020

Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.

bioRxiv : the preprint server for biology

Wang L,Muneer A,Xie L,Zhang F,Wu B,Mei L,Lenarcic EM,Feng EH,Song J,Xiong Y,Yu X,Wang C,Gheorghe C,Torralba K,Cook JG,Wan YY,Moorman NJ,Song H,Jin J,Chen X

Mon Nov 16 00:00:00 UTC 2020

δ-Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β-catenin nuclear localization and activating its downstream target genes.

Cancer medicine

Ju L,Shan L,Yin B,Song Y

Sun Mar 01 00:00:00 UTC 2020

Akt inhibition-dependent downregulation of the Wnt/β-Catenin Signaling pathway contributes to antimony-induced neurotoxicity.

The Science of the total environment

Shi W,Tang Y,Zhi Y,Li Z,Yu S,Jiang J,Zhu J,Li J,Wang F,Su L,Zhao X

Thu Oct 01 00:00:00 UTC 2020

Low-Temperature Plasma Suppresses Proliferation and Induces Apoptosis in Lung Cancer Cells by Regulating the miR-203a/BIRC5 Axis.

OncoTargets and therapy

Yang Y,Li D,Li Y,Jiang Q,Sun R,Liu J,Wu F,Miao J,Ni L,Shi X,Huang C

Fri Apr 15 00:00:00 UTC 2022

Anticancer Activity of Tetrandrine by Inducing Apoptosis in Human Breast Cancer Cell Line MDA-MB-231 In Vivo.

Evidence-based complementary and alternative medicine : eCAM

Wang CH,Yang JM,Guo YB,Shen J,Pei XH

Mon Sep 28 00:00:00 UTC 2020

Qingjie Fuzheng Granules regulates cancer cell proliferation, apoptosis and tumor angiogenesis in colorectal cancer xenograft mice via Sonic Hedgehog pathway.

Journal of gastrointestinal oncology

Zhu XQ,Yang H,Lin MH,Shang HX,Peng J,Chen WJ,Chen XZ,Lin JM

Tue Dec 01 00:00:00 UTC 2020

Anthocyanins from Aronia melanocarpa Induce Apoptosis in Caco-2 Cells through Wnt/β-Catenin Signaling Pathway.

Chemistry & biodiversity

Wei J,Yu W,Hao R,Fan J,Gao J

Sun Nov 01 00:00:00 UTC 2020

TRB3 interacts with ERK and JNK and contributes to the proliferation, apoptosis, and migration of lung adenocarcinoma cells.

Journal of cellular physiology

Cao X,Fang X,Malik WS,He Y,Li X,Xie M,Sun W,Xu Y,Liu X

Wed Jan 01 00:00:00 UTC 2020

5-HT₇ Receptor Contributes to Proliferation, Migration and Invasion in NSCLC Cells.

OncoTargets and therapy

Du X,Wang T,Wang Z,Wu X,Gu Y,Huang Q,Wang J,Xie J

Wed Apr 13 00:00:00 UTC 2022

Inhibitors of apoptosis proteins (IAPs) are associated with T-2 toxin-induced decreased collagen II in mouse chondrocytes in vitro.

Toxicon : official journal of the International Society on Toxinology

Wang W,Ji Y,Yang W,Zhang C,Angwa L,Jin B,Liu J,Lv M,Ma W,Yang J,Wang K

Sun Mar 01 00:00:00 UTC 2020

Myricanol 5-fluorobenzyloxy ether regulation of survivin pathway inhibits human lung adenocarcinoma A549 cells growth in vitro.

BMC complementary medicine and therapies

Dai GH,Chen X,Ren ZM,Dai CJ,Tong YL,Chai KQ

Thu Sep 03 00:00:00 UTC 2020

A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma.

Hepatology (Baltimore, Md.)

Wei Y,Chen X,Liang C,Ling Y,Yang X,Ye X,Zhang H,Yang P,Cui X,Ren Y,Xin X,Li H,Wang R,Wang W,Jiang F,Liu S,Ding J,Zhang B,Li L,Wang H

Wed Jan 01 00:00:00 UTC 2020

Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.

Pathology, research and practice

Dao R,Wudu M,Hui L,Jiang J,Xu Y,Ren H,Qiu X

Sun Mar 01 00:00:00 UTC 2020

ADAM10 promotes cell growth, migration, and invasion in osteosarcoma via regulating E-cadherin/β-catenin signaling pathway and is regulated by miR-122-5p.

Cancer cell international

Yuan Q,Yu H,Chen J,Song X,Sun L

Wed Apr 13 00:00:00 UTC 2022

Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells.

Cancer cell international

Yang Y,Ding L,Zhou Q,Fen L,Cao Y,Sun J,Zhou X,Liu A

Tue Apr 12 00:00:00 UTC 2022

Expression of DEC2 enhances chemosensitivity by inhibiting STAT5A in gastric cancer.

Journal of cellular biochemistry

Li H,Ma X,Xiao D,Jia Y,Wang Y

Wed May 01 00:00:00 UTC 2019

Expression of DEC2 enhances chemosensitivity by inhibiting STAT5A in gastric cancer.

Journal of cellular biochemistry

Li H,Ma X,Xiao D,Jia Y,Wang Y

Wed May 01 00:00:00 UTC 2019

Silencing TTK expression inhibits the proliferation and progression of prostate cancer.

Experimental cell research

Chen S,Wang J,Wang L,Peng H,Xiao L,Li C,Lin D,Yang K

Sun Dec 01 00:00:00 UTC 2019

CircRhoC promotes tumorigenicity and progression in ovarian cancer by functioning as a miR-302e sponge to positively regulate VEGFA.

Journal of cellular and molecular medicine

Wang LL,Zong ZH,Liu Y,Guan X,Chen S,Zhao Y

Sun Dec 01 00:00:00 UTC 2019

CAPE-pNO₂ Inhibited the Growth and Metastasis of Triple-Negative Breast Cancer via the EGFR/STAT3/Akt/E-Cadherin Signaling Pathway.

Frontiers in oncology

Huang Q,Li S,Zhang L,Qiao X,Zhang Y,Zhao X,Xiao G,Li Z

Tue Sep 29 00:00:00 UTC 2020

TROAP regulates prostate cancer progression via the WNT3/survivin signalling pathways.

Oncology reports

Ye J,Chu C,Chen M,Shi Z,Gan S,Qu F,Pan X,Yang Q,Tian Y,Wang L,Yang W,Cui X

Fri Feb 01 00:00:00 UTC 2019

miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells.

Aging

Xu X,Chen X,Xu M,Liu X,Pan B,Qin J,Xu T,Zeng K,Pan Y,He B,Sun H,Sun L,Wang S

Sun Sep 22 00:00:00 UTC 2019

Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells.

BMC complementary and alternative medicine

Que Z,Zhou Z,Luo B,Dong C,Jiang Y,Li H,Tian J

Wed Aug 07 00:00:00 UTC 2019

CpG Oligodeoxynucleotide Promotes Apoptosis of Human Bladder Cancer T24 Cells Via Inhibition of the Antiapoptotic Factors.

Technology in cancer research & treatment

Luo Y,Dong Y,Liang S,Yuan L,Men H,Zhang S,Tian S,Fu X,Dong B,Meng M

Tue Jan 01 00:00:00 UTC 2019

Synergistic effects of 7-O-geranylquercetin and siRNAs on the treatment of human breast cancer.

Life sciences

Zuo J,Jiang Y,Zhang E,Chen Y,Liang Z,Zhu J,Zhao Y,Xu H,Liu G,Liu J,Wang W,Zhang S,Zhen Y

Sat Jun 15 00:00:00 UTC 2019

Response prediction to oxaliplatin plus 5-fluorouracil chemotherapy in patients with colorectal cancer using a four-protein immunohistochemical model.

Oncology letters

Gu J,Li Z,Zhou J,Sun Z,Bai C

Thu Aug 01 00:00:00 UTC 2019

Grape Seed Proanthocyanidins Induce Autophagy and Modulate Survivin in HepG2 Cells and Inhibit Xenograft Tumor Growth in Vivo.

Nutrients

Wang L,Huang W,Zhan J

Fri Dec 06 00:00:00 UTC 2019

Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP.

Cells

Li M,Chen J,Yu X,Xu S,Li D,Zheng Q,Yin Y

Wed Apr 17 00:00:00 UTC 2019

STAT1-mediated inhibition of FOXM1 enhances gemcitabine sensitivity in pancreatic cancer.

Clinical science (London, England : 1979)

Liu C,Shi J,Li Q,Li Z,Lou C,Zhao Q,Zhu Y,Zhan F,Lian J,Wang B,Guan X,Fang L,Li Z,Wang Y,Zhou B,Yao Y,Zhang Y

Fri Mar 15 00:00:00 UTC 2019

Enhanced antitumor efficacy of arginine modified amphiphilic nanoparticles co-delivering doxorubicin and iSur-pDNA via the multiple synergistic effect.

Biomaterials

Song Y,Tang C,Yin C

Mon Jan 01 00:00:00 UTC 2018

Enhanced antitumor efficacy of arginine modified amphiphilic nanoparticles co-delivering doxorubicin and iSur-pDNA via the multiple synergistic effect.

Biomaterials

Song Y,Tang C,Yin C

Mon Jan 01 00:00:00 UTC 2018

Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.

Biomaterials

Song H,Guo T,Zhao Z,Wei Y,Luo H,Weng W,Zhang R,Zhong M,Chen C,Su J,Shen W

Sat Sep 01 00:00:00 UTC 2018

Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.

Biomaterials

Song H,Guo T,Zhao Z,Wei Y,Luo H,Weng W,Zhang R,Zhong M,Chen C,Su J,Shen W

Sat Sep 01 00:00:00 UTC 2018

Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness.

Cancer letters

Wang J,Tian L,Khan MN,Zhang L,Chen Q,Zhao Y,Yan Q,Fu L,Liu J

Wed Feb 28 00:00:00 UTC 2018

Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness.

Cancer letters

Wang J,Tian L,Khan MN,Zhang L,Chen Q,Zhao Y,Yan Q,Fu L,Liu J

Wed Feb 28 00:00:00 UTC 2018

Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhu X,Li Z,Li T,Long F,Lv Y,Liu L,Liu X,Zhan Q

Fri Jun 01 00:00:00 UTC 2018

Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhu X,Li Z,Li T,Long F,Lv Y,Liu L,Liu X,Zhan Q

Fri Jun 01 00:00:00 UTC 2018

Effect of simvastatin and microRNA-21 inhibitor on metastasis and progression of human salivary adenoid cystic carcinoma.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wang C,Li T,Yan F,Cai W,Zheng J,Jiang X,Sun J

Sat Sep 01 00:00:00 UTC 2018

Effect of simvastatin and microRNA-21 inhibitor on metastasis and progression of human salivary adenoid cystic carcinoma.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wang C,Li T,Yan F,Cai W,Zheng J,Jiang X,Sun J

Sat Sep 01 00:00:00 UTC 2018

The gastric mucosal protective effects of astragaloside IV in mnng-induced GPL rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Cai T,Zhang C,Zhao Z,Li S,Cai H,Chen X,Cai D,Liu W,Yan Y,Xie K,Pan H,Zeng X

Wed Aug 01 00:00:00 UTC 2018

The gastric mucosal protective effects of astragaloside IV in mnng-induced GPL rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Cai T,Zhang C,Zhao Z,Li S,Cai H,Chen X,Cai D,Liu W,Yan Y,Xie K,Pan H,Zeng X

Wed Aug 01 00:00:00 UTC 2018

Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.

Oxidative medicine and cellular longevity

Maryam A,Mehmood T,Yan Q,Li Y,Khan M,Ma T

Tue Sep 18 00:00:00 UTC 2018

Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.

Oxidative medicine and cellular longevity

Maryam A,Mehmood T,Yan Q,Li Y,Khan M,Ma T

Tue Sep 18 00:00:00 UTC 2018

LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein.

Biochimica et biophysica acta. Molecular basis of disease

Chen S,Wang LL,Sun KX,Liu Y,Guan X,Zong ZH,Zhao Y

Sat Sep 01 00:00:00 UTC 2018

LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein.

Biochimica et biophysica acta. Molecular basis of disease

Chen S,Wang LL,Sun KX,Liu Y,Guan X,Zong ZH,Zhao Y

Sat Sep 01 00:00:00 UTC 2018

Salinomycin suppresses cancer cell stemness and attenuates TGF-β-induced epithelial-mesenchymal transition of renal cell carcinoma cells.

Chemico-biological interactions

Liu L,Wang Q,Mao J,Qin T,Sun Y,Yang J,Han Y,Li L,Li Q

Tue Dec 25 00:00:00 UTC 2018

Salinomycin suppresses cancer cell stemness and attenuates TGF-β-induced epithelial-mesenchymal transition of renal cell carcinoma cells.

Chemico-biological interactions

Liu L,Wang Q,Mao J,Qin T,Sun Y,Yang J,Han Y,Li L,Li Q

Tue Dec 25 00:00:00 UTC 2018

Targeting HSP60 by subcutaneous injections of jetPEI/HSP60-shRNA destabilizes cytoplasmic survivin and inhibits hepatocellular carcinoma growth.

Molecular carcinogenesis

Huang YH,Lin KH,Yu JS,Wu TJ,Lee WC,Chao CC,Pan TL,Yeh CT

Sat Sep 01 00:00:00 UTC 2018

Targeting HSP60 by subcutaneous injections of jetPEI/HSP60-shRNA destabilizes cytoplasmic survivin and inhibits hepatocellular carcinoma growth.

Molecular carcinogenesis

Huang YH,Lin KH,Yu JS,Wu TJ,Lee WC,Chao CC,Pan TL,Yeh CT

Sat Sep 01 00:00:00 UTC 2018

Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.

Chinese medicine

Wang Q,Zang W,Han L,Yang L,Ye S,Ouyang J,Zhang C,Bi Y,Zhang C,Bian H

Fri Apr 08 00:00:00 UTC 2022

Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.

Chinese medicine

Wang Q,Zang W,Han L,Yang L,Ye S,Ouyang J,Zhang C,Bi Y,Zhang C,Bian H

Fri Apr 08 00:00:00 UTC 2022

RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Wang X,Liu W,Wang P,Li S

Thu Nov 01 00:00:00 UTC 2018

RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Wang X,Liu W,Wang P,Li S

Thu Nov 01 00:00:00 UTC 2018

Identification of the key genes and pathways in prostate cancer.

Oncology letters

Fan S,Liang Z,Gao Z,Pan Z,Han S,Liu X,Zhao C,Yang W,Pan Z,Feng W

Thu Nov 01 00:00:00 UTC 2018

Identification of the key genes and pathways in prostate cancer.

Oncology letters

Fan S,Liang Z,Gao Z,Pan Z,Han S,Liu X,Zhao C,Yang W,Pan Z,Feng W

Thu Nov 01 00:00:00 UTC 2018

RhPDCD5 combined with dexamethasone increases antitumor activity in multiple myeloma partially via inhibiting the Wnt signalling pathway.

Clinical and experimental pharmacology & physiology

Cheng Q,Liu L,Fu Y,Zhang Y,Yang Y,Liu J

Thu Feb 01 00:00:00 UTC 2018

RhPDCD5 combined with dexamethasone increases antitumor activity in multiple myeloma partially via inhibiting the Wnt signalling pathway.

Clinical and experimental pharmacology & physiology

Cheng Q,Liu L,Fu Y,Zhang Y,Yang Y,Liu J

Thu Feb 01 00:00:00 UTC 2018

lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.

Molecular carcinogenesis

Du Y,Wang L,Chen S,Liu Y,Zhao Y

Sat Sep 01 00:00:00 UTC 2018

Enhanced Biosynthesis Performance of Heterologous Proteins in CHO-K1 Cells Using CRISPR-Cas9.

ACS synthetic biology

Wang W,Zheng W,Hu F,He X,Wu D,Zhang W,Liu H,Ma X

Fri May 18 00:00:00 UTC 2018

Enhanced Biosynthesis Performance of Heterologous Proteins in CHO-K1 Cells Using CRISPR-Cas9.

ACS synthetic biology

Wang W,Zheng W,Hu F,He X,Wu D,Zhang W,Liu H,Ma X

Fri May 18 00:00:00 UTC 2018

[Knocking down fascin inhibits cervical cancer cell proliferation and tumorigenesis in nude mice].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

Li X,Li S,Wang X,Zhao S,Liu H

Sun Dec 30 00:00:00 UTC 2018

Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.

Cancer medicine

Wu Z,Zhu Q,Yin Y,Kang D,Cao R,Tian Q,Zhang Y,Lu S,Liu P

Sun Apr 01 00:00:00 UTC 2018

Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.

Cancer medicine

Wu Z,Zhu Q,Yin Y,Kang D,Cao R,Tian Q,Zhang Y,Lu S,Liu P

Sun Apr 01 00:00:00 UTC 2018

RELM-β promotes human pulmonary artery smooth muscle cell proliferation via FAK-stimulated surviving.

Experimental cell research

Lin C,Li X,Luo Q,Yang H,Li L,Zhou Q,Li Y,Tang H,Wu L

Wed Feb 01 00:00:00 UTC 2017

RELM-β promotes human pulmonary artery smooth muscle cell proliferation via FAK-stimulated surviving.

Experimental cell research

Lin C,Li X,Luo Q,Yang H,Li L,Zhou Q,Li Y,Tang H,Wu L

Wed Feb 01 00:00:00 UTC 2017

Anticancer effect of PP31J isolated from Physalis pubescens L. in human cervical carcinoma cells.

American journal of translational research

Zeng W,Wang Q,Chen L,Huang L,Zhao X

Tue Sep 29 00:00:00 UTC 2020

Anticancer effect of PP31J isolated from Physalis pubescens L. in human cervical carcinoma cells.

American journal of translational research

Zeng W,Wang Q,Chen L,Huang L,Zhao X

Tue Sep 29 00:00:00 UTC 2020

Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.

Oncology letters

Yan Z,Feng J,Peng J,Lai Z,Zhang L,Jin Y,Yang H,Chen W,Lin J

Fri Dec 01 00:00:00 UTC 2017

Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.

Oncology letters

Yan Z,Feng J,Peng J,Lai Z,Zhang L,Jin Y,Yang H,Chen W,Lin J

Fri Dec 01 00:00:00 UTC 2017

Inhibition of store-operated Ca²⁺ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate.

Oncology letters

Huang W,Ren C,Huang G,Liu J,Liu W,Wang L,Zhu B,Feng X,Shi J,Li J,Xia X,Jia W,Chen J,Chen Y,Jiang X

Wed Feb 01 00:00:00 UTC 2017

Inhibition of store-operated Ca²⁺ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate.

Oncology letters

Huang W,Ren C,Huang G,Liu J,Liu W,Wang L,Zhu B,Feng X,Shi J,Li J,Xia X,Jia W,Chen J,Chen Y,Jiang X

Wed Feb 01 00:00:00 UTC 2017

PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways.

Experimental and therapeutic medicine

Xu X,Cui Y,Cao L,Zhang Y,Yin Y,Hu X

Mon May 01 00:00:00 UTC 2017

PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways.

Experimental and therapeutic medicine

Xu X,Cui Y,Cao L,Zhang Y,Yin Y,Hu X

Mon May 01 00:00:00 UTC 2017

Decreased calpain activity in chronic myeloid leukemia impairs apoptosis by increasing survivin in myeloid progenitors and xiap1 in differentiating granulocytes.

Oncotarget

Huang W,Bei L,Hjort EE,Eklund EA

Tue Aug 01 00:00:00 UTC 2017

In vitro anticancer activities of osthole against renal cell carcinoma cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Liu L,Mao J,Wang Q,Zhang Z,Wu G,Tang Q,Zhao B,Li L,Li Q

Sun Oct 01 00:00:00 UTC 2017

CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.

Cell death & disease

Mao X,Li P,Wang Y,Liang Z,Liu J,Li J,Jiang Y,Bao G,Li L,Zhu B,Ren Y,Zhao X,Zhang J,Liu Y,Yang J,Liu P

Thu Jan 12 00:00:00 UTC 2017

CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.

Cell death & disease

Mao X,Li P,Wang Y,Liang Z,Liu J,Li J,Jiang Y,Bao G,Li L,Zhu B,Ren Y,Zhao X,Zhang J,Liu Y,Yang J,Liu P

Thu Jan 12 00:00:00 UTC 2017

Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma.

Oncotarget

Zheng M,Xu H,Liao XH,Chen CP,Zhang AL,Lu W,Wang L,Yang D,Wang J,Liu H,Zhou XZ,Lu KP

Tue May 02 00:00:00 UTC 2017

Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma.

Oncotarget

Zheng M,Xu H,Liao XH,Chen CP,Zhang AL,Lu W,Wang L,Yang D,Wang J,Liu H,Zhou XZ,Lu KP

Tue May 02 00:00:00 UTC 2017

Multifunctional WS₂ @Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer.

Advanced healthcare materials

Zhang C,Yong Y,Song L,Dong X,Zhang X,Liu X,Gu Z,Zhao Y,Hu Z

Tue Nov 01 00:00:00 UTC 2016

Multifunctional WS₂ @Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer.

Advanced healthcare materials

Zhang C,Yong Y,Song L,Dong X,Zhang X,Liu X,Gu Z,Zhao Y,Hu Z

Tue Nov 01 00:00:00 UTC 2016

Multifunctional WS₂ @Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer.

Advanced healthcare materials

Zhang C,Yong Y,Song L,Dong X,Zhang X,Liu X,Gu Z,Zhao Y,Hu Z

Tue Nov 01 00:00:00 UTC 2016

Multifunctional WS₂ @Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer.

Advanced healthcare materials

Zhang C,Yong Y,Song L,Dong X,Zhang X,Liu X,Gu Z,Zhao Y,Hu Z

Tue Nov 01 00:00:00 UTC 2016

Inhibitory effect on the proliferation of human heptoma induced by cell-permeable manganese superoxide dismutase.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Guo H,Zhang N,Liu D,Wang P,Ma X

Sat Oct 01 00:00:00 UTC 2016

Inhibitory effect on the proliferation of human heptoma induced by cell-permeable manganese superoxide dismutase.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Guo H,Zhang N,Liu D,Wang P,Ma X

Sat Oct 01 00:00:00 UTC 2016

A novel small-molecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells.

Oncotarget

Fu ZG,Wang L,Cui HY,Peng JL,Wang SJ,Geng JJ,Liu JD,Feng F,Song F,Li L,Zhu P,Jiang JL,Chen ZN

Tue Feb 23 00:00:00 UTC 2016

A novel small-molecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells.

Oncotarget

Fu ZG,Wang L,Cui HY,Peng JL,Wang SJ,Geng JJ,Liu JD,Feng F,Song F,Li L,Zhu P,Jiang JL,Chen ZN

Tue Feb 23 00:00:00 UTC 2016

KLF5 mediates vascular remodeling via HIF-1α in hypoxic pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Li X,He Y,Xu Y,Huang X,Liu J,Xie M,Liu X

Mon Feb 15 00:00:00 UTC 2016

Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat.

Circulation research

Cotroneo E,Ashek A,Wang L,Wharton J,Dubois O,Bozorgi S,Busbridge M,Alavian KN,Wilkins MR,Zhao L

Fri May 08 00:00:00 UTC 2015

Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat.

Circulation research

Cotroneo E,Ashek A,Wang L,Wharton J,Dubois O,Bozorgi S,Busbridge M,Alavian KN,Wilkins MR,Zhao L

Fri May 08 00:00:00 UTC 2015

Oral delivery of shRNA based on amino acid modified chitosan for improved antitumor efficacy.

Biomaterials

Zheng H,Tang C,Yin C

Sun Nov 01 00:00:00 UTC 2015

Oral delivery of shRNA based on amino acid modified chitosan for improved antitumor efficacy.

Biomaterials

Zheng H,Tang C,Yin C

Sun Nov 01 00:00:00 UTC 2015

Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells.

Autophagy

Zhao X,Fang Y,Yang Y,Qin Y,Wu P,Wang T,Lai H,Meng L,Wang D,Zheng Z,Lu X,Zhang H,Gao Q,Zhou J,Ma D

Tue Sep 13 00:00:00 UTC 2016

Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells.

Autophagy

Zhao X,Fang Y,Yang Y,Qin Y,Wu P,Wang T,Lai H,Meng L,Wang D,Zheng Z,Lu X,Zhang H,Gao Q,Zhou J,Ma D

Tue Sep 13 00:00:00 UTC 2016

Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins.

International journal of oncology

Li X,Liu X,Xu Y,He Y,Liu J,Xie M

Sun Feb 01 00:00:00 UTC 2015

Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins.

International journal of oncology

Li X,Liu X,Xu Y,He Y,Liu J,Xie M

Sun Feb 01 00:00:00 UTC 2015

Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.

International journal of oncology

Shan X,Tian LL,Zhang YM,Wang XQ,Yan Q,Liu JW

Sat Aug 01 00:00:00 UTC 2015

Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.

International journal of oncology

Shan X,Tian LL,Zhang YM,Wang XQ,Yan Q,Liu JW

Sat Aug 01 00:00:00 UTC 2015

DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.

Medical oncology (Northwood, London, England)

Huang W,Liu J,Feng X,Chen H,Zeng L,Huang G,Liu W,Wang L,Jia W,Chen J,Ren C

Wed Apr 01 00:00:00 UTC 2015

DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.

Medical oncology (Northwood, London, England)

Huang W,Liu J,Feng X,Chen H,Zeng L,Huang G,Liu W,Wang L,Jia W,Chen J,Ren C

Wed Apr 01 00:00:00 UTC 2015

The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis.

The Journal of biological chemistry

Yu C,Cui S,Zong C,Gao W,Xu T,Gao P,Chen J,Qin D,Guan Q,Liu Y,Fu Y,Li X,Wang X

Fri Aug 21 00:00:00 UTC 2015

The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis.

The Journal of biological chemistry

Yu C,Cui S,Zong C,Gao W,Xu T,Gao P,Chen J,Qin D,Guan Q,Liu Y,Fu Y,Li X,Wang X

Fri Aug 21 00:00:00 UTC 2015

RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.

Genes & cancer

Jin Y,Cao B,Zhang M,Zhan Q,Herman JG,Yu M,Guo M

Fri May 01 00:00:00 UTC 2015

RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.

Genes & cancer

Jin Y,Cao B,Zhang M,Zhan Q,Herman JG,Yu M,Guo M

Fri May 01 00:00:00 UTC 2015

PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.

Drug design, development and therapy

Yao Z,Sun B,Hong Q,Yan J,Mu D,Li J,Sheng H,Guo H

Thu Sep 15 00:00:00 UTC 2016

PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.

Drug design, development and therapy

Yao Z,Sun B,Hong Q,Yan J,Mu D,Li J,Sheng H,Guo H

Thu Sep 15 00:00:00 UTC 2016

Enhanced antitumor efficacy of folate modified amphiphilic nanoparticles through co-delivery of chemotherapeutic drugs and genes.

Biomaterials

Yu B,Tang C,Yin C

Fri Aug 01 00:00:00 UTC 2014

Enhanced antitumor efficacy of folate modified amphiphilic nanoparticles through co-delivery of chemotherapeutic drugs and genes.

Biomaterials

Yu B,Tang C,Yin C

Fri Aug 01 00:00:00 UTC 2014

KLF5 promotes hypoxia-induced survival and inhibits apoptosis in non-small cell lung cancer cells via HIF-1α.

International journal of oncology

Li X,Liu X,Xu Y,Liu J,Xie M,Ni W,Chen S

Wed Oct 01 00:00:00 UTC 2014

KLF5 promotes hypoxia-induced survival and inhibits apoptosis in non-small cell lung cancer cells via HIF-1α.

International journal of oncology

Li X,Liu X,Xu Y,Liu J,Xie M,Ni W,Chen S

Wed Oct 01 00:00:00 UTC 2014

High transfection efficiency of quantum dot-antisense oligonucleotide nanoparticles in cancer cells through dual-receptor synergistic targeting.

Nanotechnology

Zhang MZ,Li C,Fang BY,Yao MH,Ren QQ,Zhang L,Zhao YD

Fri Jun 27 00:00:00 UTC 2014

High transfection efficiency of quantum dot-antisense oligonucleotide nanoparticles in cancer cells through dual-receptor synergistic targeting.

Nanotechnology

Zhang MZ,Li C,Fang BY,Yao MH,Ren QQ,Zhang L,Zhao YD

Fri Jun 27 00:00:00 UTC 2014

Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

Wu J,Chen W,Yin Y,Zheng Z,Zou G

Sun Jun 01 00:00:00 UTC 2014

Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

Wu J,Chen W,Yin Y,Zheng Z,Zou G

Sun Jun 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Apoptosis inhibitor 4; Apoptosis inhibitor survivin; Baculoviral IAP repeat-containing protein 5; BIRC 5; EPR 1; survivin; survivin variant 3 alpha; SVV; TIAP

View more View less

Gene Aliases: AAC-11; AP14; API4; BIRC5; EPR-1; IAP4; survivin40; TIAP

View more View less

UniProt ID: (Human) O15392, (Rat) Q9JHY7, (Mouse) O70201

View more View less

Entrez Gene ID: (Human) 332, (Rat) 64041, (Mouse) 11799

View more View less

Function(s)

ubiquitin-protein transferase activity cysteine-type endopeptidase inhibitor activity protein binding microtubule binding Ran GTPase binding enzyme binding identical protein binding metal ion binding chaperone binding molecular_function zinc ion binding tubulin binding protein homodimerization activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein heterodimerization activity cofactor binding peptidase inhibitor activity

Process(es)

G2/M transition of mitotic cell cycle microtubule cytoskeleton organization transcription, DNA-templated protein phosphorylation chromosome segregation regulation of mitotic cell cycle regulation of signal transduction protein ubiquitination protein complex localization positive regulation of exit from mitosis cellular response to stem cell factor stimulus response to drug negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to peptide hormone negative regulation of neuron apoptotic process positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of mitotic cell cycle cell division establishment of chromosome localization response to glucocorticoid regulation of insulin secretion involved in cellular response to glucose stimulus regulation of type B pancreatic cell proliferation cellular response to ethanol mitotic spindle assembly inhibition of cysteine-type endopeptidase activity involved in apoptotic process apoptotic process sister chromatid cohesion positive regulation of cell proliferation protein sumoylation regulation of apoptotic process cytokinesis regulation of transcription, DNA-templated cell cycle mitotic nuclear division embryo development negative regulation of peptidase activity spindle checkpoint

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

SURVIVIN Polyclonal Antibody

SURVIVIN Antibody (10508-1-AP) in ICC/IF

Product Details

10508-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!