Proteintech

SUV39H1 Polyclonal Antibody

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SUV39H1 Antibody in Western Blot (WB) — Mouse small intestine tissue were subjected to SDS PAGE followed by western blot with 10574-1-AP (SUV39H1 antibody) at dilution of 1:100 incubated at room temperature for 1.5 hours.

SUV39H1 Antibody in Immunoprecipitation (IP) — IP result of anti-SUV39H1 (IP:10574-1-AP, 4ug; Detection:10574-1-AP 1:500) with HeLa cells lysate 2800ug.

Product Details

10574-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 3 publications 3 publications
Flow Cytometry (Flow)	Assay-dependant	-
Immunoprecipitation (IP)	0.5-4.0 µg	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	SUV39H1 Fusion Protein Ag0854 (7-271 aa encoded by BC006238) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.26 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: GCSVCCKSS WNQLQDLCRL AKLSCPALGI SKRNLYDFEV EYLCDYKKIR EQEYYLVKWR GYPDSESTWE PRQNLKCVRI LKQFHKDLER ELLRRHHRSK TPRHLDPSLA NYLVQKAKQR RALRRWEQEL NAKRSHLGRI TVENEVDLDG PPRAFVYINE YRVGEGITLN QVAVGCECQD CLWAPTGGCC PGASLHKFAY NDQGQVRLRA GLPIYECNSR CRCGYDCPNR VVQKGIRYDL CIFRTDDGRG WGVRTLEKIR KNSFVM (7-271 aa encoded by B C006238)

Target Information

This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

Nature communications

Yang G,Weng X,Zhao Y,Zhang X,Hu Y,Dai X,Liang P,Wang P,Ma L,Sun X,Hou L,Xu H,Fang M,Li Y,Jenuwein T,Xu Y,Sun A

Fri Mar 31 00:00:00 EDT 2017

Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.

Cell death & disease

Cheng W,Qi Y,Tian L,Wang B,Huang W,Chen Y

Thu Feb 23 00:00:00 EST 2017

Downregulation of HP1α suppresses proliferation of cholangiocarcinoma by restoring SFRP1 expression.

Oncotarget

Cheng W,Tian L,Wang B,Qi Y,Huang W,Li H,Chen YJ

Tue Jul 26 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: H3-K9-HMTase 1; Histone H3-K9 methyltransferase 1; Histone-lysine N-methyltransferase SUV39H1; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog; Su(var)3-9 homolog 1; Suppressor of variegation 3-9 homolog 1; Suv39h histone methyltransferase

Gene Aliases: AI852103; AL022883; DXHXS7466e; H3-K9-HMTase 1; KMT1A; MG44; mIS6; RGD1565028; SUV39H; SUV39H1

UniProt ID: (Human) O43463, (Mouse) O54864

Entrez Gene ID: (Human) 6839, (Mouse) 20937, (Rat) 302553

Molecular Function: chromatin/chromatin-binding, or -regulatory protein histone modifying enzyme