This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.
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Protein Aliases: H3-K9-HMTase 1; Histone H3-K9 methyltransferase 1; Histone-lysine N-methyltransferase SUV39H1; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog; Su(var)3-9 homolog 1; Suppressor of variegation 3-9 homolog 1; Suv39h histone methyltransferase
Gene Aliases: AI852103; AL022883; DXHXS7466e; H3-K9-HMTase 1; KMT1A; MG44; mIS6; RGD1565028; SUV39H; SUV39H1
Molecular Function: chromatin/chromatin-binding, or -regulatory protein histone modifying enzyme