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Invitrogen
SWAP70 Polyclonal Antibody
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FIGURE: 1 / 2
SWAP70 Antibody (PA5-23248) in IHC (P)
Immunohistochemistry analysis of SWAP70 in formalin-fixed paraffin-embedded human tonsil germinal center. Samples were incubated with SWAP70 polyclonal antibody (Product # PA5-23248) using a dilution of 10 µg/mL. Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.
Product Details
PA5-23248
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 1-50 of human SWAP70.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The amino acid sequence used as immunogen for the antibody is 85% homologous in Chicken.
Target Information
SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3, 4, 5-trisphosphate binding. SWAP70 acts as a link between the recognition of specific switch regions and causation of a DNA break and is involved in both nuclear events and in signaling B-cell activation. As a guanine nucleotide exchange factor (GEF) it transduces signals from tyrosine kinase receptors to RAC, independent of RAS. As a multiple functional signaling protein, and a component of SWAP enzyme complex, it mediates signaling of membrane ruffling by tyrosine kinase growth factor receptors, actin cytoskeleton and cell protrusion. It is widely expressed in most tissues, mature B-cells, including those associated with mucosa-associated tissue and bronchus-associated tissue, monocytes and macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ39540; KIAA0640 protein; SWAP switching B-cell complex 70kDa subunit; SWAP switching B-cell complex subunit 70; SWAP-70; Switch-associated protein 70; unnamed protein product
Gene Aliases: HSPC321; KIAA0640; SWAP-70; SWAP70
UniProt ID: (Human) Q9UH65
Entrez Gene ID: (Human) 23075
positive regulation of cytosolic calcium ion concentration
regulation of actin polymerization or depolymerization
somatic cell DNA recombination
negative regulation of actin filament depolymerization
positive regulation of actin filament bundle assembly
regulation of protein localization
negative regulation of cell-cell adhesion mediated by integrin
isotype switching
actin filament bundle assembly
regulation of small GTPase mediated signal transduction
positive regulation of mast cell chemotaxis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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