This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: PVAPKPPSRG LLDGLVNGAA SSAGIPEPPR LQGRGGELFA KRQSRADRYV VEGTPGPGLG PR
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 80%.
SYNPO2L was initially identified as a novel heart-enriched gene that encodes a cytoskeletal protein highly expressed in the Z-disc of heart and skeletal muscle, associates with actin and interacts with a-actinin. It is a member of the synaptopodin family, sharing greatest homology with Synaptopodin 2. Recent studies have shown that SYNPO2L, while primarily localized to the sarcomere, can also translocate to the nucleus. A knockdown of SYNPO2L in zebrafish resulted in aberrant cardiac and skeletal muscle development and function, suggesting that it is a critical component of the sarcomere and plays an important role in muscle development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Synaptopodin 2-like protein
Gene Aliases: SYNPO2L
UniProt ID: (Human) Q9H987
Entrez Gene ID: (Human) 79933