Search
Bethyl Laboratories
Sequestosome-1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 3
Sequestosome-1 Antibody (A302-855A) in IHC (P)
Detection of human Sequestosome-1 by immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-Sequestosome-1 (Product # A302-855A) (Lot 1) used at a dilution of 1:1,000 (1 µg/mL). Detection: Vector Laboratories ImmPACT NovaRED Peroxidase Substrate.
Product Details
A302-855A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 325 and 375 of Human Sequestosome-1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Rat and Orangutan
Target Information
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: autophagy receptor p62; EBI3-associated protein of 60 kDa; EBI3-associated protein p60; EBIAP; oxidative stress induced; oxidative stress induced like; p62; p62 transcript variant 4; p62 transcript variant 5; phosphotyrosine independent ligand for the Lck SH2 domain p62; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Sequestosome-1; STONE14; Ubiquitin-binding protein p62; unnamed protein product
Gene Aliases: A170; DMRV; EBIAP; FTDALS3; NADGP; ORCA; OSF-6; Osi; OSIL; p60; p62; p62B; PDB3; SQSTM1; STAP; STONE14; ZIP3
UniProt ID: (Human) Q13501, (Mouse) Q64337
Entrez Gene ID: (Human) 8878, (Mouse) 18412
protein kinase C binding
protein binding
zinc ion binding
enzyme binding
protein kinase binding
protein binding, bridging
receptor tyrosine kinase binding
ubiquitin protein ligase binding
ionotropic glutamate receptor binding
signaling receptor activity
SH2 domain binding
identical protein binding
ubiquitin binding
macromolecular complex binding
metal ion binding
K63-linked polyubiquitin binding
ubiquitin-dependent protein binding
protein sequestering activity
molecular sequestering activity
molecular condensate scaffold activity
transcription cofactor activity
protein homodimerization activity
negative regulation of transcription from RNA polymerase II promoter
mitophagy
mitophagy
pexophagy
temperature homeostasis
immune system process
response to ischemia
transcription from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
protein import into nucleus
autophagy
apoptotic process
endosome organization
protein localization
positive regulation of autophagy
regulation of mitochondrion organization
endosomal transport
macroautophagy
cell differentiation
protein catabolic process
negative regulation of protein ubiquitination
cellular response to stress
toll-like receptor 4 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
intracellular signal transduction
aggrephagy
positive regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
regulation of Ras protein signal transduction
regulation of protein complex stability
brown fat cell proliferation
protein K63-linked ubiquitination
protein targeting to vacuole involved in autophagy
energy homeostasis
response to mitochondrial depolarisation
negative regulation of ferroptosis
membraneless organelle assembly
positive regulation of long-term synaptic potentiation
positive regulation of protein localization to plasma membrane
protein localization to perinuclear region of cytoplasm
positive regulation of protein phosphorylation
positive regulation of macroautophagy
protein heterooligomerization
mitophagy in response to mitochondrial depolarization
regulation of nucleic acid-templated transcription
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support