|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to the third cytoplasmic loop of human 5-HT1B Receptor.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.7|
|Contains||0.01% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-20650 detects 5-HT1B Receptor in human samples.
PA1-20650 has been successfully used in immunohistochemistry (paraffin) procedures.
The PA1-20650 immunogen is a synthetic peptide corresponding to the third cytoplasmic loop of human 5-HT1B Receptor.
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. The 5-HT1B receptor has been reported to be expressed in a variety of neurons predominantly in the central nervous system. It has been suggested that Human 5-HT1B receptors are located somatodendritically on GABAergic and peptidergic caudate-putamen neurons which project to the substantia nigra and globus pallidus, where these receptors are presynaptic. 5-HT1B expression has also been seen in heart, blood vessels, and eye.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.