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Shiga toxin 2 (Setoxaximab Biosimilar) Recombinant Human Monoclonal Antibody
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FIGURE: 1 / 1
Shiga toxin 2 (Setoxaximab Biosimilar) Antibody (MA5-41996) in SDS-PAGE
SDS-PAGE analysis of the recombinant Escherichia coli Stx2/SLT-II protein expressed in CHO cells using a Shiga toxin 2 (Setoxaximab Biosimilar) monoclonal antibody (Product # MA5-41996). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
Product Details
MA5-41996
Product Specifications
Species Reactivity
Bacteria
Host/Isotype
Human
/ IgG1, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Escherichia coli Stx2/SLT-II
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
MA5-41996 is a chimeric antibody. The variable regions from one species have been grafted to the backbone of the other species.
Target Information
Shiga toxin 2 (Stx2) is another variant of the Shiga toxins produced by certain strains of Shigella dysenteriae and Escherichia coli. Structurally, like Shiga toxin 1, Stx2 is an AB5 toxin composed of one A subunit and five B subunits. The A subunit has an N-glycosidase activity that disrupts protein synthesis by cleaving a specific adenine residue from the 28S rRNA of the 60S ribosomal subunit, leading to cell death. The B subunits form a pentamer that binds to the glycosphingolipid receptor Gb3 (globotriaosylceramide) on the surface of host cells, facilitating the entry of the A subunit into the cells. Functionally, Stx2 is highly cytotoxic and plays a crucial role in the pathogenicity of the bacterial strains that produce it, leading to severe diseases such as hemolytic uremic syndrome (HUS), which is characterized by acute kidney failure, hemolytic anemia, and thrombocytopenia. Stx2 is known to be more potent and associated with more severe disease outcomes compared to Stx1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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