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SnoN Polyclonal Antibody
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Product Details
BS-5945R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SKIL, amino acids 301-400.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: putative transcription factor; SKI-like oncogene; Ski-like protein; Ski-related oncogene; ski-related oncogene snoN; Ski-related protein; ski/sno related; unnamed protein product
Gene Aliases: SKIL; Skir; SNO; SnoA; SnoI; SnoN
UniProt ID: (Human) P12757, (Mouse) Q60665
Entrez Gene ID: (Human) 6498, (Rat) 114208, (Mouse) 20482
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
protein binding
protein domain specific binding
identical protein binding
macromolecular complex binding
SMAD binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
molecular_function
DNA binding
transcription corepressor activity
protein complex binding
negative regulation of transcription from RNA polymerase II promoter
blastocyst formation
lymphocyte homeostasis
transforming growth factor beta receptor signaling pathway
spermatogenesis
skeletal muscle tissue development
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
cell differentiation
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
response to cytokine
negative regulation of cell differentiation
response to antibiotic
regulation of neurogenesis
positive regulation of axonogenesis
regulation of cell cycle
muscle structure development
lens fiber cell differentiation
response to growth factor
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
cell cycle arrest
regulation of apoptotic process
protein homotrimerization
protein heterotrimerization
transcription from RNA polymerase II promoter
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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