Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Osenses
Sortilin Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
OSS00041G-500UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from rat Sortilin conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Sortilin.
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Glycoprotein 110; Gp110; mNTR3; Neurotensin receptor 3; NTR3; Sortilin
Gene Aliases: 2900053A11Rik; AI852375; Nt3; Ntr3; Nts3; Ntsr3; Sort1
UniProt ID: (Mouse) Q6PHU5, (Rat) O54861
Entrez Gene ID: (Mouse) 20661, (Rat) 83576
ossification
transport
Golgi to endosome transport
endocytosis
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
multicellular organism development
endosome to lysosome transport
extrinsic apoptotic signaling pathway via death domain receptors
regulation of gene expression
myotube differentiation
vesicle organization
cell differentiation
endosome transport via multivesicular body sorting pathway
response to insulin
nerve growth factor signaling pathway
negative regulation of fat cell differentiation
glucose import
neurotrophin TRK receptor signaling pathway
plasma membrane to endosome transport
negative regulation of lipoprotein lipase activity
intracellular protein transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support