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Invitrogen
Sortilin Monoclonal Antibody (CL6528)
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Product Details
MA5-31438
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
C. elegans
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CL6528
Immunogen
Recombinant protein fragment of Human SORT1 (Product #RP-88683).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LERNCEEKDY TIWLAHSTDP EDYEDGCILG YKEQFLRLRK SSVCQNGRDY VVTKQPSICL CSLEDFLCDF GYYRPENDSK CVEQPELKGH DLEFCLYGRE EHLTTNGYRK IPGDKCQGGV NPVREVKD
Highest antigen sequence indentity to the following orthologs: Mouse - 89%, Rat - 89%.
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 100 kDa NT receptor; Glycoprotein 95; Gp95; mNTR3; Neurotensin receptor 3; NT3; NTR3; Sortilin
Gene Aliases: 2900053A11Rik; AI852375; Gp95; LDLCQ6; NT3; NTR3; Ntsr3; SORT1
UniProt ID: (Human) Q99523, (Mouse) Q6PHU5
Entrez Gene ID: (Human) 6272, (Mouse) 20661
ossification
Golgi to endosome transport
endocytosis
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
multicellular organism development
endosome to lysosome transport
extrinsic apoptotic signaling pathway via death domain receptors
regulation of gene expression
myotube differentiation
vesicle organization
endosome transport via multivesicular body sorting pathway
response to insulin
nerve growth factor signaling pathway
negative regulation of fat cell differentiation
glucose import
neurotrophin TRK receptor signaling pathway
plasma membrane to endosome transport
negative regulation of lipoprotein lipase activity
positive regulation of epithelial cell apoptotic process
transport
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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