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Invitrogen
Spectrin beta-3 Polyclonal Antibody
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Product Details
PA1-46007
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
C-terminal region between residue 2340 and 2390 of Spectrin beta 3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: Hela whole cell extract.
Target Information
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Beta-III spectrin; beta-spectrin 3; cytoskeletal protein; glutamate transporter EAAT4-associated protein 41; membrane associated cytoskeletal protein; Spectrin Beta; spectrin beta 3; spectrin beta chain, brain 2; Spectrin beta chain, non-erythrocytic 2; spectrin beta III sigma 2; spectrin, non-erythroid beta chain 2; Spinocerebellar ataxia 5 protein
Gene Aliases: GTRAP41; KIAA0302; mKIAA0302; SCA5; SCAR14; Spnb3; SPTBN2
UniProt ID: (Human) O15020
Entrez Gene ID: (Human) 6712, (Mouse) 20743
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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