PA5-28574 targets SYK in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28574 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 283 of Human SYK.
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This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: p72-Syk; Spleen tyrosine kinase; Tyrosine-protein kinase SYK
Gene Aliases: p72-Syk; SYK
UniProt ID: (Human) P43405
Entrez Gene ID: (Human) 6850