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SynGAP Antibody (PA5-141109) in IHC (P)
Immunohistochemistry analysis of SynGAP in paraffin-embedded human uterus tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with SynGAP Polyclonal antibody (Product # PA5-141109) using a dilution of 1:100 for 30 minutes a... View More
Product Details
PA5-141109
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human SynGAP aa 1100-1250.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2932561
Target Information
Synaptic Ras-GTPase activating protein (SynGAP) is a PDZ-domain interacting protein expressed almost exclusively in the brain. SynGAP has been shown to be a major component of postsynaptic density and associates with post synaptic density 95 kDa (PSD-95), a synaptic scaffold protein, and synaptic N-methyl-D-aspartate (NMDA) receptors. SynGAP Ras-GTPase activity has also been shown to be inhibited by phosphorylation by CaM kinase II, another abundant protein located in the postsynaptic density. It has been proposed that SynGAP may function as a negative regulator of MAP Kinase activation in the absence of active NMDA receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp761G1421; Neuronal R; Neuronal RasGAP; OTTHUMP00000209046; p135 SynGAP; Ras GTPase-activating protein SynGAP; Ras/Rap GTPase-activating protein SynGAP; synaptic Ras GTPase activating protein 1 homolog; synaptic Ras GTPase activating protein, 135kDa; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1
Gene Aliases: Gm1963; KIAA1938; MRD5; RASA1; RASA5; SYNGAP; SYNGAP1
UniProt ID: (Human) Q96PV0, (Mouse) F6SEU4
Entrez Gene ID: (Human) 8831, (Rat) 192117, (Mouse) 240057
MAPK cascade
Ras protein signal transduction
pattern specification process
visual learning
dendrite development
receptor clustering
regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
negative regulation of Ras protein signal transduction
regulation of synaptic plasticity
regulation of long-term neuronal synaptic plasticity
negative regulation of axonogenesis
signal transduction
regulation of synapse structure or activity
regulation of GTPase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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