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Invitrogen
SynGAP Polyclonal Antibody
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Product Details
PA5-37909
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
C. elegans
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence DEDEIHPLLIRDR-C, from the N-terminus of SYNGAP1 (aa60-72)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with human, rat, dog, pig and cow based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
Synaptic Ras-GTPase activating protein (SynGAP) is a PDZ-domain interacting protein expressed almost exclusively in the brain. SynGAP has been shown to be a major component of postsynaptic density and associates with post synaptic density 95 kDa (PSD-95), a synaptic scaffold protein, and synaptic N-methyl-D-aspartate (NMDA) receptors. SynGAP Ras-GTPase activity has also been shown to be inhibited by phosphorylation by CaM kinase II, another abundant protein located in the postsynaptic density. It has been proposed that SynGAP may function as a negative regulator of MAP Kinase activation in the absence of active NMDA receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp761G1421; Neuronal R; Neuronal RasGAP; OTTHUMP00000209046; ras GTPase-activating protein SynGAP; Ras/Rap GTPase-activating protein SynGAP; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1
Gene Aliases: Gm1963; Syngap; Syngap1
UniProt ID: (Mouse) F6SEU4
Entrez Gene ID: (Mouse) 240057
signal transduction
Ras protein signal transduction
pattern specification process
visual learning
dendrite development
regulation of GTPase activity
receptor clustering
regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
negative regulation of Ras protein signal transduction
regulation of synaptic plasticity
regulation of long-term neuronal synaptic plasticity
negative regulation of axonogenesis
regulation of synapse structure or activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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