|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (86 CELTVWSRQGKAGKT 100) of Syncollin protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.05-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Syncollin is a 134 amino acid, small peripheral membrane protein abundantly expressed in pancreatic acinar cells and is tightly associated with the lumenal side of the zymogen granule membrane. It contains intrachain disulfide bonds. Syncollin is also known to associate with lipid rafts in a cholesterol-dependent manner. In pancreatic acinar cells, syncollin helps in exocytosis and also plays a role in maturation and/or concentration of zymogens in zymogen granules. Reports suggest that syncollin may also have a pore-forming activity on membranes and regulate exocytosis in some exocrine tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.