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Syntaxin-1A-1B Polyclonal Antibody
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Product Details
OSS00013W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 60-110 of mouse Syntaxin-1A conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and human.
Specificity of this antibody: Syntaxin-1A and Syntaxin-1B.
Target Information
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE domain, and an N-terminal regulatory domain. Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adipocyte; adiponectin; FP17469; HGNC:11433; Neuron-specific antigen HPC-1; P35A; P35B; STX1A; STX1B-deltaTM; Synaptotagmin-associated 35 kDa protein; syntaxin 1 a; syntaxin 1A (brain); syntaxin 1A (brain)-like; syntaxin 1B1; syntaxin 1B2; Syntaxin 2; syntaxin a/b; Syntaxin-1A; Syntaxin-1B; Syntaxin-1B1; Syntaxin-1B2; unnamed protein product
Gene Aliases: GEFSP9; HPC-1; P35-1; Sap; STX1; STX1A; STX1B; STX1B1; STX1B2; Stx1bl; Stx2; SYN1A; Syn1b
UniProt ID: (Human) Q16623, (Human) P61266, (Mouse) O35526, (Rat) P32851, (Mouse) P61264, (Rat) P61265
Entrez Gene ID: (Human) 6804, (Human) 112755, (Mouse) 20907, (Rat) 116470, (Mouse) 56216, (Rat) 24923
SNARE binding
SNAP receptor activity
protein binding
myosin binding
calcium channel inhibitor activity
chloride channel inhibitor activity
kinase binding
protein binding, bridging
myosin head/neck binding
identical protein binding
ATP-dependent protein binding
ion channel binding
macromolecular complex binding
calcium-dependent protein binding
receptor binding
protein kinase binding
glycoprotein binding
protein domain specific binding
protein heterodimerization activity
protein N-terminus binding
SNARE protein
positive regulation of neurotransmitter secretion
neurotransmitter transport
intracellular protein transport
exocytosis
vesicle fusion
response to gravity
positive regulation of norepinephrine secretion
regulation of synaptic vesicle priming
synaptic vesicle exocytosis
synaptic vesicle docking
vesicle-mediated transport
protein sumoylation
calcium ion regulated exocytosis
regulation of exocytosis
insulin secretion
secretion by cell
positive regulation of catecholamine secretion
SNARE complex assembly
regulated exocytosis
positive regulation of exocytosis
positive regulation of calcium ion-dependent exocytosis
hormone secretion
vesicle docking
synaptic vesicle endocytosis
regulation of insulin secretion
protein localization to membrane
modulation of excitatory postsynaptic potential
positive regulation of excitatory postsynaptic potential
vesicle docking involved in exocytosis
regulation of gene expression
negative regulation of neuron projection development
synaptic vesicle fusion to presynaptic active zone membrane
calcium ion-regulated exocytosis of neurotransmitter
regulation of synaptic activity
spontaneous neurotransmitter secretion
negative regulation of synaptic vesicle recycling
positive regulation of spontaneous neurotransmitter secretion
negative regulation of macropinocytosis
transport
protein transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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