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The target sequence has 94% sequence homology with guinea pig.
Suggested positive control: antigen standard for TACR1 (transient overexpression lysate), SF9 whole cell membrane extracts.
Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.
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Protein Aliases: neurokinin 1 receptor; neurokinin receptor 1; NK-1 receptor; NK-1R; Nk1 receptor; SPR; substance P receptor; Substance-P receptor; Tachykinin receptor 1; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
Gene Aliases: NK1R; NKIR; SPR; TAC1R; TACR1
UniProt ID: (Human) P25103, (Mouse) P30548, (Rat) P14600
Entrez Gene ID: (Human) 6869, (Mouse) 21336, (Rat) 24807
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