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Invitrogen

TAP2 Polyclonal Antibody

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TAP2 Polyclonal Antibody

Product Details

PA5-102438

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TAP2(Accession Q03519), corresponding to amino acid residues E538-F588.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2851843

Product Specific Information

Antibody detects endogenous levels of total TAP2.

Target Information

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ABC transporter, MHC 2; Antigen peptide transporter 2; APT2; ATP dependent transport protein family member; ATP-binding cassette sub-family B member 3; ATP-binding cassette, sub-family B (MDR/TAP), member 3; Histocompatibility antigen modifier 2; Peptide supply factor 2; Peptide transporter involved in antigen processing 2; Peptide transporter PSF2; Peptide transporter TAP2; PSF-2; putative peptide pump; putative; Really interesting new gene 11 protein; RING11; TAP2; Transporter 2 ABC (ATP binding cassette); transporter 2 ATP-binding cassette sub-family B; transporter 2, ABC (ATP binding cassette); transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); transporter associated with antigen processing; unnamed protein product

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Gene Aliases: ABC18; ABCB3; AI462429; APT2; Cim; D6S217E; Ham-2; Ham2; jas; MHC1D2; MTP2; PSF-2; PSF2; RING11; Tap-2; TAP2; Y1

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UniProt ID: (Human) Q03519, (Mouse) P36371, (Rat) P36372

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Entrez Gene ID: (Human) 6891, (Mouse) 21355, (Rat) 24812

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Function(s)
nucleotide binding protein binding ATP binding peptide antigen-transporting ATPase activity peptide-transporting ATPase activity ATPase activity MHC class Ib protein binding MHC protein binding peptide antigen binding metal ion binding TAP1 binding tapasin binding ABC-type transporter activity peptide transmembrane transporter activity peptide transporter activity MHC class I protein binding ATPase activity, coupled to transmembrane movement of substances protein homodimerization activity ADP binding TAP2 binding protein heterodimerization activity transporter activity ATP-binding cassette (ABC) transporter
Process(es)
T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity response to molecule of bacterial origin adaptive immune response immune system process antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent peptide antigen assembly with MHC class I protein complex protein transport peptide transport antigen processing and presentation of endogenous peptide antigen via MHC class I cytosol to ER transport peptide antigen transport transmembrane transport positive regulation of antigen processing and presentation of peptide antigen via MHC class I protein complex assembly transport intracellular transport of viral protein in host cell protection from natural killer cell mediated cytotoxicity metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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