|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues V(386) E S A L N K S E P FL T W L(400) of the PDZ-binding domain of human TAZ.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500 - 1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-4218 detects the TAZ protein in human, mouse, and rat samples.
PA1-4218 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~49 kDa protein representing TAZ in MDCK cells.
The PA1-4218 immunogen is a synthetic peptide corresponding to residues V(386) E S A L N K S E P FL T W L(400) of the 49kDa human TAZ protein.
Highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. A novel transcriptional co-activator, TAZ (transcriptional co-activator with PDZ-binding motif) functions as a 14-3-3-binding molecule. TAZ may link events at the plasma membrane and cytoskeleton to nuclear transcription in a manner that can be regulated by 14-3-3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.