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Invitrogen
TBX18 Polyclonal Antibody
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Product Details
PA5-69067
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the N-terminal region of rat TBX18
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 86%; Dog: 86%; Guinea Pig: 86%; Horse: 86%; Human: 79%; Mouse: 100%; Rabbit: 86%; Rat: 100%
Target Information
The T-box (Tbx) motif is present in a family of genes whose structural features and expression patterns support their involvement in developmental gene regulation. The Tbx gene family are largely conserved throughout metazoan evolution, and these genes code for putative transcription factors that share a uniquely defining DNA-binding domain. Tbx genes are a family of developmental regulators with more than 20 members recently identified in invertebrates and vertebrates. Mutations in Tbx genes are associated with the onset of several human diseases. Our understanding of functional mechanisms of Tbx products has come mainly from the prototypical T/Brachyury, which is a transcription activator. The Tbx genes constitute a family of transcriptional regulatory genes that are implicated in a variety of developmental processes ranging from the formation of germ layers to the organizational patterning of the central nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: T-box protein 14; T-box protein 15; T-box transcription factor TBX18; TBX14; TBX15
Entrez Gene ID: (Rat) 315870
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
RNA polymerase II transcription corepressor activity
molecular_function
DNA binding
transcription factor activity, sequence-specific DNA binding
protein homodimerization activity
protein heterodimerization activity
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
somitogenesis
positive regulation of mesenchymal cell proliferation
sinoatrial node development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
sensory perception of sound
biological_process
anterior/posterior axis specification
morphogenesis of embryonic epithelium
positive regulation of cell-cell adhesion
cell differentiation
anatomical structure formation involved in morphogenesis
positive regulation of epithelial cell proliferation
smooth muscle cell differentiation
negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
ureter development
cochlea morphogenesis
positive regulation of mesenchymal cell proliferation involved in ureter development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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